| http://purl.uniprot.org/citations/12595342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12595342 | http://www.w3.org/2000/01/rdf-schema#comment | "The nonreceptor tyrosine kinase focal adhesion kinase (FAK) is a point of convergence for signals from extracellular matrix, soluble factors, and mechanical stimuli. Targeted disruption of the fak gene in mice leads to death at embryonic day 8.5 (E8.5). FAK-/-embryos have severely impaired blood vessel development. Gene expression and in vitro differentiation studies revealed that endothelial cell differentiation was comparable in FAK-/- and wild-type E8.5 embryos. We examined the role of FAK in blood vessel morphogenesis using an in vitro tubulogenesis assay and three different culture systems: FAK+/+ and FAK-/- embryoid bodies, FAK+/+ and FAK-/-endothelial cells, and human umbilical vein endothelial cells expressing antisense FAK, a dominant-negative fragment of FAK, or wild-type FAK. In all of these systems, endothelial cells deficient in FAK expression or function displayed a severely reduced ability to form tubules in Matrigel. These studies demonstrate clearly that the vascular defects in FAK-/-mice result from the inability of FAK-deficient endothelial cells to organize themselves into vascular networks, rather than from defects in tissue-specific differentiation."xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.0000055016.36679.23"xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://purl.uniprot.org/core/author | "Jin F."xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://purl.uniprot.org/core/author | "Gardner D.G."xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://purl.uniprot.org/core/author | "Ilic D."xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://purl.uniprot.org/core/author | "Damsky C.H."xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://purl.uniprot.org/core/author | "Baumbusch C."xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://purl.uniprot.org/core/author | "Kovacic B."xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://purl.uniprot.org/core/author | "McDonagh S."xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12595342 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://purl.uniprot.org/core/pages | "300-307"xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://purl.uniprot.org/core/title | "Focal adhesion kinase is required for blood vessel morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/12595342 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12595342 |
| http://purl.uniprot.org/citations/12595342 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12595342 |
| http://purl.uniprot.org/uniprot/P34152#attribution-0B4C575E655237788DC55B678B168FF3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12595342 |
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| http://purl.uniprot.org/uniprot/#_A0A2I3BPK4-mappedCitation-12595342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12595342 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQ85-mappedCitation-12595342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12595342 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BR46-mappedCitation-12595342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12595342 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRG7-mappedCitation-12595342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12595342 |
| http://purl.uniprot.org/uniprot/#_B1ARA9-mappedCitation-12595342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12595342 |
| http://purl.uniprot.org/uniprot/#_B1ARB3-mappedCitation-12595342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12595342 |