| http://purl.uniprot.org/citations/12595424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12595424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12595424 | http://www.w3.org/2000/01/rdf-schema#comment | "Two-component regulatory signal transduction systems are widely distributed among bacteria and enable the organisms to make coordinated changes in gene expression in response to a variety of environmental stimuli. The genome sequence of Mycobacterium tuberculosis contains 11 complete two-component systems, four isolated homologous regulators, and three isolated homologous sensors. We have constructed defined mutations in six of these genes and measured virulence in a SCID mouse model. Mice infected with four of the mutants (deletions of devR, tcrXY, trcS, and kdpDE) died more rapidly than those infected with wild-type bacteria. The other two mutants (narL and Rv3220c) showed no change compared to the wild-type H37Rv strain. The most hypervirulent mutant (devRdelta) also grew more rapidly in the acute stage of infection in immunocompetent mice and in gamma interferon-activated macrophages. These results define a novel class of genes in this pathogen whose presence slows down its multiplication in vivo or increases its susceptibility to host killing mechanisms. Thus, M. tuberculosis actively maintains a balance between its own survival and that of the host."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.71.3.1134-1140.2003"xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.71.3.1134-1140.2003"xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/author | "Stoker N.G."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/author | "Stoker N.G."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/author | "Smith D.A."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/author | "Smith D.A."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/author | "Bancroft G.J."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/author | "Bancroft G.J."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/author | "Parish T."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/author | "Parish T."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/author | "Casali N."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/author | "Casali N."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/author | "Kendall S."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/author | "Kendall S."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/name | "Infect. Immun."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/name | "Infect. Immun."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/pages | "1134-1140"xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/pages | "1134-1140"xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/title | "Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/12595424 | http://purl.uniprot.org/core/title | "Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis."xsd:string |