| http://purl.uniprot.org/citations/12605902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12605902 | http://www.w3.org/2000/01/rdf-schema#comment | "The opioid receptor-like 1 receptor is a novel member of the opioid receptor family and its endogenous peptide ligand has been termed nociceptin and orphanin FQ. Activation of the opioid receptor-like 1 receptor by nociceptin/orphanin FQ in vivo produces hyperalgesia when this peptide is given supraspinally but analgesia at the spinal level. Nociceptin/orphanin FQ also reverses stress-induced analgesia, suggesting that the peptide has anti-opioid properties. Nociceptin/orphanin FQ knockout mice show alterations in pain sensitivity and stress responses and display increased morphine dependence, suggesting an interaction of the nociceptin/orphanin FQ system with classical opioid receptor function. To determine if the behavioural phenotype of nociceptin/orphanin FQ knockout mice reflects changes in either opioid receptor-like 1 or classical opioid receptor expression, we have carried out quantitative autoradiography of the opioid receptor-like 1, mu-, delta- and kappa-opioid receptors in the brains of these animals. Receptor density was measured on coronal sections from wild-type, heterozygous and homozygous mice using [(3)H]nociceptin, [(3)H][D-Ala(2)-N-methyl-Phe(4)-Gly(5) ol] enkephalin, [(3)H]deltorphin-I, or [(3)H](-)-N-methyl-N-[7-(1-pyrrodinyl)-1-oxospiro[4,5]dec-8-yl]-4-benzofuranacetamide to label opioid receptor-like 1, mu-, delta- and kappa-receptors, respectively. A region-specific up-regulation of the opioid receptor-like 1 receptor (up to 135%) was seen in brains from homozygous mice. Mu-Receptors also showed significant differences between genotypes whilst changes in delta- and kappa-receptors were minor. In conclusion the region-specific up-regulation of the opioid receptor-like 1 receptor indicates a tonic role for nociceptin/orphanin FQ in some brain structures and may suggest the peptide regulates the receptor expression in these regions. The changes in the opioid receptor-like 1 receptor may relate to the anxiogenic phenotype of these animals but the observed change in mu-receptors does not correlate with altered morphine responses."xsd:string |
| http://purl.uniprot.org/citations/12605902 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0306-4522(02)00750-9"xsd:string |
| http://purl.uniprot.org/citations/12605902 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/12605902 | http://purl.uniprot.org/core/author | "Clarke S."xsd:string |
| http://purl.uniprot.org/citations/12605902 | http://purl.uniprot.org/core/author | "Pintar J.E."xsd:string |
| http://purl.uniprot.org/citations/12605902 | http://purl.uniprot.org/core/author | "Kitchen I."xsd:string |
| http://purl.uniprot.org/citations/12605902 | http://purl.uniprot.org/core/author | "Hill R.G."xsd:string |
| http://purl.uniprot.org/citations/12605902 | http://purl.uniprot.org/core/author | "Hsu M.S."xsd:string |
| http://purl.uniprot.org/citations/12605902 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12605902 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/12605902 | http://purl.uniprot.org/core/pages | "157-168"xsd:string |
| http://purl.uniprot.org/citations/12605902 | http://purl.uniprot.org/core/title | "Nociceptin/orphanin FQ knockout mice display up-regulation of the opioid receptor-like 1 receptor and alterations in opioid receptor expression in the brain."xsd:string |
| http://purl.uniprot.org/citations/12605902 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/12605902 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12605902 |
| http://purl.uniprot.org/citations/12605902 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12605902 |
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| http://purl.uniprot.org/uniprot/#_B7ZMX9-mappedCitation-12605902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12605902 |
| http://purl.uniprot.org/uniprot/#_P35377-mappedCitation-12605902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12605902 |
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