| http://purl.uniprot.org/citations/12606261 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12606261 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12606261 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcium channels are multimeric proteins consisting of pore-forming (alpha(1)) and auxiliary (alpha(2)delta, beta, gamma) subunits. The auxiliary alpha(2)delta-subunit regulates calcium current density and activation/inactivation kinetics when co-expressed with some, but not all, alpha(1)-subunits. Here we report the differential expression of three alpha(2)delta-subunit cDNAs in rat atria, atrial myocytes and ventricle, and demonstrate that IGF-1 selectively increases the expression of the alpha(2)delta-3 mRNA in the atria. mRNA encoding the alpha(2)delta-1- and alpha(2)delta-2-subunits, but not the alpha(2)delta-3-subunit, is detected in the rat ventricle whereas all three transcripts are found in atrial tissue. Analysis of the rat alpha(2)delta-1 cDNA sequence indicates that the atria express the alpha(2)delta-1e alternatively spliced isoform of this gene. The complete cDNA sequences of the alpha(2)delta-2- and alpha(2)delta-3-subunits from rat atria were determined and found to share 96% and 95% identity, respectively, with their counterparts in mouse. Treatment of acutely cultured atrial myocytes with IGF-1 caused a significant increase of the amount of alpha(2)delta-3, but not alpha(2)delta-1 or alpha(2)delta-2, mRNA. Both L-type and T-type calcium currents are recorded from cardiac tissue although their expression is regionally specific and changes with age and physiological state. Differential regulation of the expression of alpha(2)delta-subunit genes is likely to contribute to alterations in the expression of calcium current in the mammalian heart."xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0022-2828(02)00313-9"xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0022-2828(02)00313-9"xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.org/dc/terms/identifier | "doi:10.1016/S0022-2828(02)00313-9"xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/author | "Best P.M."xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/author | "Best P.M."xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/author | "Chu P.-J."xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/author | "Chu P.-J."xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/name | "J. Mol. Cell. Cardiol."xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/name | "J. Mol. Cell. Cardiol."xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/pages | "207-215"xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/pages | "207-215"xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/title | "Molecular cloning of calcium channel alpha(2)delta-subunits from rat atria and the differential regulation of their expression by IGF-1."xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/title | "Molecular cloning of calcium channel alpha(2)delta-subunits from rat atria and the differential regulation of their expression by IGF-1."xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/12606261 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12606261 |
| http://purl.uniprot.org/citations/12606261 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12606261 |
| http://purl.uniprot.org/citations/12606261 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12606261 |
| http://purl.uniprot.org/citations/12606261 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12606261 |
| http://purl.uniprot.org/uniprot/Q8CFG7 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12606261 |