http://purl.uniprot.org/citations/12606572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12606572 | http://www.w3.org/2000/01/rdf-schema#comment | "Kid is a kinesin-like DNA-binding protein known to be involved in chromosome movement during mitosis, although its actual motor function has not been demonstrated. Here, we describe the initial characterization of Kid as a microtubule-based motor using optical trapping microscopy. A bacterially expressed fusion protein consisting of a truncated Kid fragment (amino acids 1-388 or 1-439) is indeed an active microtubule motor with an average speed of approximately 160 nm/s, and the polarity of movement is plus end directed. We could not detect processive movement of either monomeric Kid or dimerizing chimeric Kid; however, low levels of processivity (a few steps) cannot be detected with our method. These results are consistent with Kid having a role in chromosome congression in vivo, where it would be responsible for the polar ejection forces acting on the chromosome arms."xsd:string |
http://purl.uniprot.org/citations/12606572 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg102"xsd:string |
http://purl.uniprot.org/citations/12606572 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
http://purl.uniprot.org/citations/12606572 | http://purl.uniprot.org/core/author | "Edamatsu M."xsd:string |
http://purl.uniprot.org/citations/12606572 | http://purl.uniprot.org/core/author | "Tokai-Nishizumi N."xsd:string |
http://purl.uniprot.org/citations/12606572 | http://purl.uniprot.org/core/author | "Toyoshima Y.Y."xsd:string |
http://purl.uniprot.org/citations/12606572 | http://purl.uniprot.org/core/author | "Yajima J."xsd:string |
http://purl.uniprot.org/citations/12606572 | http://purl.uniprot.org/core/author | "Watai-Nishii J."xsd:string |
http://purl.uniprot.org/citations/12606572 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
http://purl.uniprot.org/citations/12606572 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
http://purl.uniprot.org/citations/12606572 | http://purl.uniprot.org/core/pages | "1067-1074"xsd:string |
http://purl.uniprot.org/citations/12606572 | http://purl.uniprot.org/core/title | "The human chromokinesin Kid is a plus end-directed microtubule-based motor."xsd:string |
http://purl.uniprot.org/citations/12606572 | http://purl.uniprot.org/core/volume | "22"xsd:string |
http://purl.uniprot.org/citations/12606572 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12606572 |
http://purl.uniprot.org/citations/12606572 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12606572 |
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http://purl.uniprot.org/uniprot/Q14807 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12606572 |