| http://purl.uniprot.org/citations/12606591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12606591 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously shown that (i). leptin and leptin receptor (Ob-R) are expressed in the human endometrium, and (ii). leptin secretion is regulated in blastocyst and endometrial epithelial cell (EEC) co-cultures. Interleukin-1beta (IL-1beta) up-regulates leptin and Ob-R, and both cytokines up-regulate beta3 integrin expression in EEC. In the present investigation we examined the effect of leptin on the expression of the IL-1 system in EEC and endometrial stromal cells (ESC) cultured in a medium containing insulin, leptin or IL-1beta (0-3 nmol/l). Leptin stimulated IL-1 antagonist (IL-1Ra), IL-1beta secretion and expression of IL-1 receptor type I (IL-1R tI) in both cell types. IL-1beta and IL-1Ra secretion were down-regulated by IL-1R tI blockade using specific antibodies. Interestingly, leptin partially neutralized this effect. The blockade of Ob-R neutralized the effects of both leptin and IL-1beta on expression of the IL-1beta system and beta3 integrin and on phosphorylation of signal transducer and activator of transcription 3 (Stat3). These results suggest that leptin regulates the IL-1 system and that the blockade of functional Ob-R impairs leptin and IL-1beta functions at the endometrial level. Leptin could be an important molecule for implantation and a molecular mediator for actions of the IL-1 system. The fact that leptin, in the absence of IL-1, can trigger the expression of markers of endometrial receptivity and of the invasive trophoblast phenotype (as does IL-1), suggest that leptin could substitute for these IL-1 functions during the implantation process."xsd:string |
| http://purl.uniprot.org/citations/12606591 | http://purl.org/dc/terms/identifier | "doi:10.1093/molehr/gag022"xsd:string |
| http://purl.uniprot.org/citations/12606591 | http://purl.uniprot.org/core/author | "Gonzalez R.R."xsd:string |
| http://purl.uniprot.org/citations/12606591 | http://purl.uniprot.org/core/author | "Leavis P.C."xsd:string |
| http://purl.uniprot.org/citations/12606591 | http://purl.uniprot.org/core/author | "Leary K."xsd:string |
| http://purl.uniprot.org/citations/12606591 | http://purl.uniprot.org/core/author | "Petrozza J.C."xsd:string |
| http://purl.uniprot.org/citations/12606591 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12606591 | http://purl.uniprot.org/core/name | "Mol Hum Reprod"xsd:string |
| http://purl.uniprot.org/citations/12606591 | http://purl.uniprot.org/core/pages | "151-158"xsd:string |
| http://purl.uniprot.org/citations/12606591 | http://purl.uniprot.org/core/title | "Leptin regulation of the interleukin-1 system in human endometrial cells."xsd:string |
| http://purl.uniprot.org/citations/12606591 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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