| http://purl.uniprot.org/citations/12609831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12609831 | http://www.w3.org/2000/01/rdf-schema#comment | "Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8), which exists in 2 isoforms including one possessing cytoplasmic tyrosine motifs, is expressed only on human eosinophils, basophils, and mast cells. Until now, its function was unknown. Here we define a novel function of Siglec-8 on eosinophils. Siglec-8 cross-linking with antibodies rapidly generated caspase-3-like activity and reduced eosinophil viability through induction of apoptosis. The pancaspase inhibitor benzyloxycarbonyl (Cbz)-Val-Ala-Asp-(Ome)-fluoromethyl ketone (zVAD-FMK) completely blocked this response, implicating caspases in Siglec-8 cross-linking-induced apoptosis. Eosinophil survival-promoting cytokines such as interleukin 5 (IL-5) and granulocyte-macrophage colony-stimulating factor (GM-CSF) failed to block apoptosis and instead enhanced the sensitivity of eosinophils to undergo apoptosis in response to Siglec-8 antibody. Siglec-8 activation may provide a useful therapeutic approach to reduce numbers of eosinophils (and perhaps basophils and mast cells) in disease states where these cells are important."xsd:string |
| http://purl.uniprot.org/citations/12609831 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2002-10-3058"xsd:string |
| http://purl.uniprot.org/citations/12609831 | http://purl.uniprot.org/core/author | "Aizawa H."xsd:string |
| http://purl.uniprot.org/citations/12609831 | http://purl.uniprot.org/core/author | "Hudson S.A."xsd:string |
| http://purl.uniprot.org/citations/12609831 | http://purl.uniprot.org/core/author | "Bochner B.S."xsd:string |
| http://purl.uniprot.org/citations/12609831 | http://purl.uniprot.org/core/author | "Nutku E."xsd:string |
| http://purl.uniprot.org/citations/12609831 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12609831 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12609831 | http://purl.uniprot.org/core/pages | "5014-5020"xsd:string |
| http://purl.uniprot.org/citations/12609831 | http://purl.uniprot.org/core/title | "Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12609831 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/12609831 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12609831 |
| http://purl.uniprot.org/citations/12609831 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12609831 |
| http://purl.uniprot.org/uniprot/#_C9JT30-mappedCitation-12609831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12609831 |
| http://purl.uniprot.org/uniprot/#_Q9NYZ4-mappedCitation-12609831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12609831 |
| http://purl.uniprot.org/uniprot/Q9NYZ4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12609831 |
| http://purl.uniprot.org/uniprot/C9JT30 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12609831 |