RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/12610304http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12610304http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12610304http://www.w3.org/2000/01/rdf-schema#comment"Nonhuman primates represent the most relevant model organisms to understand the biology of Homo sapiens. The recent divergence and associated overall sequence conservation between individual members of this taxon have nonetheless largely precluded the use of primates in comparative sequence studies. We used sequence comparisons of an extensive set of Old World and New World monkeys and hominoids to identify functional regions in the human genome. Analysis of these data enabled the discovery of primate-specific gene regulatory elements and the demarcation of the exons of multiple genes. Much of the information content of the comprehensive primate sequence comparisons could be captured with a small subset of phylogenetically close primates. These results demonstrate the utility of intraprimate sequence comparisons to discover common mammalian as well as primate-specific functional elements in the human genome, which are unattainable through the evaluation of more evolutionarily distant species."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.org/dc/terms/identifier"doi:10.1126/science.1081331"xsd:string
http://purl.uniprot.org/citations/12610304http://purl.org/dc/terms/identifier"doi:10.1126/science.1081331"xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"Ovcharenko I."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"Ovcharenko I."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"Pachter L."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"Pachter L."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"Rubin E.M."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"Rubin E.M."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"McAuliffe J."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"McAuliffe J."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"Lewis K.D."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"Lewis K.D."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"Boffelli D."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"Boffelli D."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"Ovcharenko D."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/author"Ovcharenko D."xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/pages"1391-1394"xsd:string
http://purl.uniprot.org/citations/12610304http://purl.uniprot.org/core/pages"1391-1394"xsd:string