| http://purl.uniprot.org/citations/12614326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12614326 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of the present studies was to determine the effects of reduced or absent serotonin (5-HT) transporters (5-HTTs) on 5-HT2A and 5-HT2C receptors. The density of 5-HT2C receptors was significantly increased in the amygdala and choroid plexus of 5-HTT knockout mice. On the other hand, the density of 5-HT2A receptors was significantly increased in the hypothalamus and septum, but reduced in the striatum, of 5-HTT knockout mice. However, 5-HT2A mRNA was not changed in any brain region measured. 5-HT2C mRNA was significantly reduced in the choroid plexus and lateral habenula nucleus of these mice. The function of 5-HT2A receptors was evaluated by hormonal responses to (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). Oxytocin, but not adrenocorticotrophic hormone or corticosterone, responses to DOI were significantly greater in 5-HTT knockout mice. In addition, Gq and G11 proteins were not significantly changed in any brain region measured. The present results suggest that the constitutive alteration in the function of 5-HTTs changes the density of 5-HT2A and 5-HT2C receptors in a brain region-specific manner. These changes may not be mediated by alterations in their gene expression or in the level of Gq/11 proteins. The alterations in these receptors may be related to the altered behaviors of 5-HTT knockout mice."xsd:string |
| http://purl.uniprot.org/citations/12614326 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.2003.01607.x"xsd:string |
| http://purl.uniprot.org/citations/12614326 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/12614326 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/12614326 | http://purl.uniprot.org/core/author | "Garcia F."xsd:string |
| http://purl.uniprot.org/citations/12614326 | http://purl.uniprot.org/core/author | "Murphy D.L."xsd:string |
| http://purl.uniprot.org/citations/12614326 | http://purl.uniprot.org/core/author | "Wichems C.H."xsd:string |
| http://purl.uniprot.org/citations/12614326 | http://purl.uniprot.org/core/author | "Van de Kar L.D."xsd:string |
| http://purl.uniprot.org/citations/12614326 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12614326 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/12614326 | http://purl.uniprot.org/core/pages | "1256-1265"xsd:string |
| http://purl.uniprot.org/citations/12614326 | http://purl.uniprot.org/core/title | "Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice."xsd:string |
| http://purl.uniprot.org/citations/12614326 | http://purl.uniprot.org/core/volume | "84"xsd:string |
| http://purl.uniprot.org/citations/12614326 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12614326 |
| http://purl.uniprot.org/citations/12614326 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12614326 |
| http://purl.uniprot.org/uniprot/#_B1ATN4-mappedCitation-12614326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12614326 |
| http://purl.uniprot.org/uniprot/#_B2RUD4-mappedCitation-12614326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12614326 |
| http://purl.uniprot.org/uniprot/#_Q32MU4-mappedCitation-12614326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12614326 |
| http://purl.uniprot.org/uniprot/#_P35363-mappedCitation-12614326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12614326 |
| http://purl.uniprot.org/uniprot/#_Q8BZI5-mappedCitation-12614326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12614326 |
| http://purl.uniprot.org/uniprot/#_P34968-mappedCitation-12614326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12614326 |
| http://purl.uniprot.org/uniprot/#_Q5NCR5-mappedCitation-12614326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12614326 |
| http://purl.uniprot.org/uniprot/#_Q5UBE7-mappedCitation-12614326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12614326 |
| http://purl.uniprot.org/uniprot/#_Q60857-mappedCitation-12614326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12614326 |