| http://purl.uniprot.org/citations/12615910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12615910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12615910 | http://www.w3.org/2000/01/rdf-schema#comment | "The function of the nonreceptor tyrosine kinase c-Src as a plasma membrane-associated molecular effector of a variety of extracellular stimuli is well known. Here, we show that c-Src is also present within mitochondria, where it phosphorylates cytochrome c oxidase (Cox). Deleting the c-src gene reduces Cox activity, and this inhibitory effect is restored by expressing exogenous c-Src. Furthermore, reducing endogenous Src kinase activity down-regulates Cox activity, whereas activating Src has the opposite effect. Src-induced Cox activity is required for normal function of cells that require high levels of ATP, such as mitochondria-rich osteoclasts. The peptide hormone calcitonin, which inhibits osteoclast function, also down-regulates Cox activity. Increasing Src kinase activity prevented the inhibitory effect of calcitonin on Cox activity and osteoclast function. These results suggest that c-Src plays a previously unrecognized role in maintaining cellular energy stores by activating Cox in mitochondria."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200209098"xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200209098"xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/author | "Miyazaki T."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/author | "Miyazaki T."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/author | "Tanaka S."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/author | "Tanaka S."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/author | "Baron R."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/author | "Baron R."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/author | "Neff L."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/author | "Neff L."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/author | "Horne W.C."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/author | "Horne W.C."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/pages | "709-718"xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/pages | "709-718"xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/title | "Regulation of cytochrome c oxidase activity by c-Src in osteoclasts."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/title | "Regulation of cytochrome c oxidase activity by c-Src in osteoclasts."xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/volume | "160"xsd:string |
| http://purl.uniprot.org/citations/12615910 | http://purl.uniprot.org/core/volume | "160"xsd:string |