| http://purl.uniprot.org/citations/12619925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12619925 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteoporosis, a multifactorial common disease, is believed to result from the interplay of multiple environmental and genetic determinants, including factors that regulate bone mineral density. Interleukin-1 (IL-1) is one of the most potent bone-resorbing factors, and interleukin-1-associated kinase 1 (IRAK1) is an essential effector of the IL-1 receptor signaling cascade. In genetic studies of two independent populations of postmenopausal women (cohort A: 220 individuals and cohort T: 126 individuals) from separated geographical regions of Japan, we found that radial bone mineral density levels had similar associations with IRAK1 genotypes in both populations. Two amino acid-substituting variations in the gene, encoding Phe196Ser and Ser532Leu, were in complete linkage disequilibrium (D' = 1.0000, r2 = 1.0000, chi2 = 192.000, p = 1.2 x 10(-43)), and we found two exclusive haplotypes (196F/532S, frequency 0.74; 196S/532L, frequency 0.26) of the IRAK1 gene among our test subjects. In both populations, a significant association with decreased radial bone mineral density was identified with haplotype 196F/532S (in cohort A: r = 0.21, p = 0.0017; in cohort T: r = 0.23, p = 0.011). Radial bone mineral density was lowest among 196F/532S homozygotes, highest among 196S/532L homozygotes, and intermediate among heterozygotes. Accelerated bone loss also correlated with the 196F/532S haplotype in a 5-year follow-up. These results suggest that variation of IRAK1 may be an important determinant of postmenopausal osteoporosis, in part through the mechanism of accelerated postmenopausal bone loss."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.org/dc/terms/identifier | "doi:10.1359/jbmr.2003.18.3.419"xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/author | "Ito H."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/author | "Iwasaki H."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/author | "Inoue S."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/author | "Emi M."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/author | "Shiraki M."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/author | "Ezura Y."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/author | "Ishida R."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/author | "Hosoi T."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/author | "Orimo H."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/name | "J Bone Miner Res"xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/pages | "419-423"xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/title | "Association of a haplotype (196Phe/532Ser) in the interleukin-1-receptor-associated kinase (IRAK1) gene with low radial bone mineral density in two independent populations."xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/12619925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12619925 |
| http://purl.uniprot.org/citations/12619925 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12619925 |
| http://purl.uniprot.org/uniprot/#_L8E7M9-mappedCitation-12619925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12619925 |
| http://purl.uniprot.org/uniprot/#_P51617-mappedCitation-12619925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12619925 |
| http://purl.uniprot.org/uniprot/P51617 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12619925 |
| http://purl.uniprot.org/uniprot/L8E7M9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12619925 |