http://purl.uniprot.org/citations/12622783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12622783 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate HLA-associated genetic susceptibility to Meniere's disease in relation to type II collagen (CII) autoimmunity status, HLA-DRB1 genotyping and ELISA measurement of anti-CII antibody were performed in 41 Korean patients with Meniere's disease. In the anti-CII positive subgroup (20%) of patients, the frequency of HLA-DRB1*0405 was significantly increased (uncorrected) compared with both controls (63% vs 16%) and anti-CII negative patients (63% vs 12%). In the anti-CII negative subgroup, HLA-DRB1*1201 was significantly increased (uncorrected) (27% vs 10%) and DRB1*13 was decreased (6% vs 24%) compared with controls; these alleles appeared to confer susceptibility and resistance to the development of the disease. Association of HLA-DRB1*0405 with anti-CII positive Meniere's disease in this study suggests that it shares a specific HLA-DR sequence, QRRAA, as a genetic susceptibility factor with the anti-CII positive rheumatoid arthritis. In conclusion, whilst type II collagen autoimmunity may have a partial role in Meniere's disease, different HLA-DR alleles may also be associated with either susceptibility or resistance to the development of the disease in relation to anti-CII antibody status."xsd:string |
http://purl.uniprot.org/citations/12622783 | http://purl.org/dc/terms/identifier | "doi:10.1034/j.1399-0039.2003.610112.x"xsd:string |
http://purl.uniprot.org/citations/12622783 | http://purl.uniprot.org/core/author | "Park M.H."xsd:string |
http://purl.uniprot.org/citations/12622783 | http://purl.uniprot.org/core/author | "Oh S.H."xsd:string |
http://purl.uniprot.org/citations/12622783 | http://purl.uniprot.org/core/author | "Kim C.S."xsd:string |
http://purl.uniprot.org/citations/12622783 | http://purl.uniprot.org/core/author | "Lim M.J."xsd:string |
http://purl.uniprot.org/citations/12622783 | http://purl.uniprot.org/core/author | "Koo J.W."xsd:string |
http://purl.uniprot.org/citations/12622783 | http://purl.uniprot.org/core/author | "Yoo T.J."xsd:string |
http://purl.uniprot.org/citations/12622783 | http://purl.uniprot.org/core/author | "Chang S.O."xsd:string |
http://purl.uniprot.org/citations/12622783 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
http://purl.uniprot.org/citations/12622783 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
http://purl.uniprot.org/citations/12622783 | http://purl.uniprot.org/core/pages | "99-103"xsd:string |
http://purl.uniprot.org/citations/12622783 | http://purl.uniprot.org/core/title | "Association of HLA-DR and type II collagen autoimmunity with Meniere's disease."xsd:string |
http://purl.uniprot.org/citations/12622783 | http://purl.uniprot.org/core/volume | "61"xsd:string |
http://purl.uniprot.org/citations/12622783 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12622783 |
http://purl.uniprot.org/citations/12622783 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12622783 |
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