| http://purl.uniprot.org/citations/12624007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12624007 | http://www.w3.org/2000/01/rdf-schema#comment | "Human essential hypertension is a complex polygenic trait with underlying genetic components that remain unknown. The stroke-prone spontaneously hypertensive rat (SHRSP) is a model of human essential hypertension, and a number of reproducible blood pressure regulation quantitative trait loci have been found to map to rat chromosome 2. The SP.WKYGla2c* congenic strain was produced by introgressing a region of rat chromosome 2 from the normotensive Wistar Kyoto (WKY) strain into the genetic background of the SHRSP. Systolic and diastolic blood pressures were significantly reduced in the SP.WKYGla2c* compared with the SHRSP parental strain (198/134+/-6.1/3.3 versus 172/120+/-3.8/3.4 mm Hg; F=15.8/8.1, P=0.0009/0.013). Genome-wide microarray expression profiling was undertaken to identify differentially expressed genes among the parental SHRSP, WKY, and congenic strain. We identified a significant reduction in expression of glutathione S-transferase mu-type 2, a gene involved in the defense against oxidative stress. Quantitative reverse transcription-polymerase chain reaction relative to a beta-actin standard confirmed the microarray results with SHRSP mRNA at 8.56 x 10(-4) +/-1.6 x 10(-4) compared with SP.WKYGla2c* 3.67 x 10(-3)+/-2.8 x 10(-4) (95% CI -3.9 x 10(-3) to -1.8 x 10(-3); P=0.0034) and WKY 4.03 x 10(-3)+/-5.1 x 10(-4); (95% CI -5.4 x 10(-3) to -8.9 x 10(-4); P=0.027). We also identified regions of conserved synteny, each containing the Gstm2 gene, on mouse chromosome 3 and human chromosome 1."xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.hyp.0000047103.07205.03"xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/author | "Carr F.J."xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/author | "McBride M.W."xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/author | "Lee W.K."xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/author | "Graham D."xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/author | "Dominiczak A.F."xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/author | "Brosnan M.J."xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/author | "Clark J.S."xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/author | "Charchar F.J."xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/author | "Anderson N.H."xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/pages | "847-853"xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/title | "Microarray analysis of rat chromosome 2 congenic strains."xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/12624007 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12624007 |
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| http://purl.uniprot.org/uniprot/#_A0A8I6A1B0-mappedCitation-12624007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12624007 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AJ43-mappedCitation-12624007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12624007 |
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| http://purl.uniprot.org/uniprot/#_B6DYQ2-mappedCitation-12624007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12624007 |