| http://purl.uniprot.org/citations/12626535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12626535 | http://www.w3.org/2000/01/rdf-schema#comment | "Pre-TCR complexes are thought to signal in a ligand-independent manner because they are constitutively targeted to lipid rafts. We report that ligand-independent signaling is not a unique capability of the pre-TCR complex. Indeed, the TCR alpha subunit restores development of pT alpha-deficient thymocytes to the CD4(+)CD8(+) stage even in the absence of conventional MHC class I and class II ligands. Moreover, we found that pre-TCR and alpha beta TCR complexes exhibit no appreciable difference in their association with lipid rafts, suggesting that ligand-independence is a function of the CD4(-)CD8(-) (DN) thymocytes in which pre-TCR signaling occurs. In agreement, we found that only CD44(-)CD25(+) DN thymocytes (DN3) enabled activation of extracellular signal-regulated kinases by the pre-TCR complex. DN thymocytes also exhibited a lower signaling threshold relative to CD4(+)CD8(+) thymocytes, which was associated with both the markedly elevated lipid raft content of their plasma membranes and more robust capacitative Ca(2+) entry. Taken together these data suggest that cell-autonomous, ligand-independent signaling is primarily a property of the thymocytes in which pre-TCR signaling occurs."xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.170.6.2853"xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/author | "Rhodes M."xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/author | "Ciofani M."xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/author | "Wiest D.L."xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/author | "Haks M.C."xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/author | "Belkowski S.M."xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/author | "Hugo P."xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/author | "Lefebvre J.M."xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/author | "Zuniga-Pflucker J.C."xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/author | "Trop S."xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/pages | "2853-2861"xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/title | "Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells."xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://purl.uniprot.org/core/volume | "170"xsd:string |
| http://purl.uniprot.org/citations/12626535 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12626535 |
| http://purl.uniprot.org/citations/12626535 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12626535 |
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| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-12626535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12626535 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-12626535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12626535 |
| http://purl.uniprot.org/uniprot/#_P06342-mappedCitation-12626535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12626535 |