| http://purl.uniprot.org/citations/12628165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12628165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12628165 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in parkin, which encodes a RING domain protein associated with ubiquitin ligase activity, lead to autosomal recessive Parkinson's disease characterized by midbrain dopamine neuron loss. Here we show that parkin functions in a multiprotein ubiquitin ligase complex that includes the F-box/WD repeat protein hSel-10 and Cullin-1. HSel-10 serves to target the parkin ubiquitin ligase activity to cyclin E, an hSel-10-interacting protein previously implicated in the regulation of neuronal apoptosis. Consistent with the notion that cyclin E is a substrate of the parkin ubiquitin ligase complex, parkin deficiency potentiates the accumulation of cyclin E in cultured postmitotic neurons exposed to the glutamatergic excitotoxin kainate and promotes their apoptosis. Furthermore, parkin overexpression attenuates the accumulation of cyclin E in toxin-treated primary neurons, including midbrain dopamine neurons, and protects them from apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(03)00084-9"xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(03)00084-9"xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/author | "Staropoli J.F."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/author | "Staropoli J.F."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/author | "Schulman B."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/author | "Schulman B."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/author | "Abeliovich A."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/author | "Abeliovich A."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/author | "Martinat C."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/author | "Martinat C."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/author | "Demireva E."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/author | "Demireva E."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/author | "McDermott C."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/author | "McDermott C."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/pages | "735-749"xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/pages | "735-749"xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/title | "Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity."xsd:string |
| http://purl.uniprot.org/citations/12628165 | http://purl.uniprot.org/core/title | "Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity."xsd:string |