| http://purl.uniprot.org/citations/12628186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12628186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12628186 | http://www.w3.org/2000/01/rdf-schema#comment | "Granzyme A (GzmA) induces a caspase-independent cell death pathway characterized by single-stranded DNA nicks and other features of apoptosis. A GzmA-activated DNase (GAAD) is in an ER associated complex containing pp32 and the GzmA substrates SET, HMG-2, and Ape1. We show that GAAD is NM23-H1, a nucleoside diphosphate kinase implicated in suppression of tumor metastasis, and its specific inhibitor (IGAAD) is SET. NM23-H1 binds to SET and is released from inhibition by GzmA cleavage of SET. After GzmA loading or CTL attack, SET and NM23-H1 translocate to the nucleus and SET is degraded, allowing NM23-H1 to nick chromosomal DNA. GzmA-treated cells with silenced NM23-H1 expression are resistant to GzmA-mediated DNA damage and cytolysis, while cells overexpressing NM23-H1 are more sensitive."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00150-8"xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00150-8"xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/author | "Fan Z."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/author | "Fan Z."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/author | "Oh D.Y."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/author | "Oh D.Y."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/author | "Beresford P.J."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/author | "Beresford P.J."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/author | "Lieberman J."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/author | "Lieberman J."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/pages | "659-672"xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/pages | "659-672"xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/title | "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/title | "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor."xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/12628186 | http://purl.uniprot.org/core/volume | "112"xsd:string |