| http://purl.uniprot.org/citations/12628187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12628187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12628187 | http://www.w3.org/2000/01/rdf-schema#comment | "We used representational difference analysis to identify homozygous genomic deletions selected during tumor progression in the mouse NF2 and TP53 tumor model. We describe a deletion targeting DOCK4, a member of the CDM gene family encoding regulators of small GTPases. DOCK4 specifically activates Rap GTPase, enhancing the formation of adherens junctions. DOCK4 mutations are present in a subset of human cancer cell lines; a recurrent missense mutant identified in human prostate and ovarian cancers encodes a protein that is defective in Rap1 activation. The engulfment defect of C. elegans mutants lacking the CDM gene ced-5 is rescued by wild-type DOCK4, but not by the mutant allele. Expression of wild-type, but not mutant, DOCK4 in mouse osteosarcoma cells with a deletion of the endogenous gene suppresses growth in soft agar and tumor invasion in vivo. DOCK4 therefore encodes a CDM family member that regulates intercellular junctions and is disrupted during tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00155-7"xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00155-7"xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Saito M."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Saito M."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "McClatchey A.I."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "McClatchey A.I."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Settleman J."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Settleman J."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Bell D.W."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Bell D.W."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Haber D.A."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Haber D.A."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "van den Heuvel S."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "van den Heuvel S."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Wahrer D.C.R."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Wahrer D.C.R."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Reynolds P."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Reynolds P."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Lake R."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Lake R."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Paulding C."xsd:string |
| http://purl.uniprot.org/citations/12628187 | http://purl.uniprot.org/core/author | "Paulding C."xsd:string |