| http://purl.uniprot.org/citations/12629221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12629221 | http://www.w3.org/2000/01/rdf-schema#comment | "The antigen-presenting cells that initiate and maintain MHC class II-associated organ-specific autoimmune diseases are poorly defined. We now describe a new T cell antigen receptor (TCR) transgenic (Tg) model of inflammatory skin disease in which keratinocytes activate and are the primary target of autoreactive CD4(+) T cells. We previously generated keratin 14 (K14)-A(beta)b mice expressing MHC class II only on thymic cortical epithelium. CD4(+) T cells from K14-A(beta)b mice fail to undergo negative selection and thus have significant autoreactivity. The TCR genes from an autoreactive K14-A(beta)b CD4 hybridoma were cloned to produce a TCR Tg mouse, 2-2-3. 2-2-3 TCR Tg cells are negatively selected in WT C57BL6 mice but not in 2-2-3K14-A(beta)b mice. Interestingly, a significant number of mice that express both the K14-A(beta)b transgene and the autoreactive 2-2-3 TCR spontaneously develop inflammatory skin disease with mononuclear infiltrates, induction of MHC class II expression on keratinocytes, and T helper 1 cytokines. Disease can be induced by skin inflammation but not solely by activation of T cells. Thus, cutaneous immunopathology can be directed through antigen presentation by tissue-resident keratinocytes to autoreactive TCR Tg CD4(+) cells."xsd:string |
| http://purl.uniprot.org/citations/12629221 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0437899100"xsd:string |
| http://purl.uniprot.org/citations/12629221 | http://purl.uniprot.org/core/author | "Fan L."xsd:string |
| http://purl.uniprot.org/citations/12629221 | http://purl.uniprot.org/core/author | "Lo D."xsd:string |
| http://purl.uniprot.org/citations/12629221 | http://purl.uniprot.org/core/author | "Busser B.W."xsd:string |
| http://purl.uniprot.org/citations/12629221 | http://purl.uniprot.org/core/author | "Oukka M."xsd:string |
| http://purl.uniprot.org/citations/12629221 | http://purl.uniprot.org/core/author | "Laufer T.M."xsd:string |
| http://purl.uniprot.org/citations/12629221 | http://purl.uniprot.org/core/author | "Lifsted T.Q."xsd:string |
| http://purl.uniprot.org/citations/12629221 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12629221 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/12629221 | http://purl.uniprot.org/core/pages | "3386-3391"xsd:string |
| http://purl.uniprot.org/citations/12629221 | http://purl.uniprot.org/core/title | "Antigen presentation by keratinocytes directs autoimmune skin disease."xsd:string |
| http://purl.uniprot.org/citations/12629221 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/12629221 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12629221 |
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