| http://purl.uniprot.org/citations/12629511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12629511 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquitin-mediated proteolysis of cell cycle regulators is a major element of the cell cycle control. The anaphase-promoting complex (APC/C) is a large multisubunit ubiquitin-protein ligase required for the ubiquitination and degradation of G1 and mitotic checkpoint regulators. APC/C-dependent proteolysis regulates cyclin levels in G1, and triggers the separation of sister chromatids at the metaphase-anaphase transition and the destruction of mitotic cyclins at the end of mitosis. Furthermore, it was recently shown that APC/C regulates the degradation of crucial regulators of signal transduction pathways. We report here gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 and APC8/CDC23 which are known to be key function elements. The experimental expression of a truncation mutant of APC8/CDC23 subunit (CDC23DeltaTPR) leads to abnormal levels of APC/C targets such as cyclin B1 and disturbs the cell cycle progression of colon epithelial cells through mitosis. Overall, these data support the hypothesis of a deleterious role of these mutations during colorectal carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206224"xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/author | "Navarro C."xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/author | "Puisieux A."xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/author | "Lorca T."xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/author | "Moyret-Lalle C."xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/author | "Saurin J.C."xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/author | "Couzon F."xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/author | "Surbiguet-Clippe C."xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/pages | "1486-1490"xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/title | "Alterations of anaphase-promoting complex genes in human colon cancer cells."xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12629511 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12629511 |
| http://purl.uniprot.org/citations/12629511 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12629511 |
| http://purl.uniprot.org/uniprot/Q9UJX2#attribution-711B9EDDF5CE6B3D9C9BCD8BA84E713A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12629511 |
| http://purl.uniprot.org/uniprot/#_A0A3B3ISD2-mappedCitation-12629511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12629511 |
| http://purl.uniprot.org/uniprot/#_B2RCW0-mappedCitation-12629511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12629511 |
| http://purl.uniprot.org/uniprot/#_B4DK74-mappedCitation-12629511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12629511 |
| http://purl.uniprot.org/uniprot/#_Q13042-mappedCitation-12629511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12629511 |
| http://purl.uniprot.org/uniprot/#_L8E7J3-mappedCitation-12629511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12629511 |
| http://purl.uniprot.org/uniprot/#_Q59EG1-mappedCitation-12629511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12629511 |