| http://purl.uniprot.org/citations/12629550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12629550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12629550 | http://www.w3.org/2000/01/rdf-schema#comment | "All living organisms use ion channels to regulate the transport of ions across cellular membranes. Certain ion channels are classed as voltage-dependent because they have a voltage-sensing structure that induces their pores to open in response to changes in the cell membrane voltage. Until recently, the voltage-dependent K+, Ca2+ and Na+ channels were regarded as a unique development of eukaryotic cells, adapted to accomplish specialized electrical signalling, as exemplified in neurons. Here we present the functional characterization of a voltage-dependent K+ (K(V)) channel from a hyperthermophilic archaebacterium from an oceanic thermal vent. This channel possesses all the functional attributes of classical neuronal K(V) channels. The conservation of function reflects structural conservation in the voltage sensor as revealed by specific, high-affinity interactions with tarantula venom toxins, which evolved to inhibit eukaryotic K(V) channels."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01473"xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01473"xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/author | "Lee A."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/author | "Lee A."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/author | "MacKinnon R."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/author | "MacKinnon R."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/author | "Ruta V."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/author | "Ruta V."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/pages | "180-185"xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/pages | "180-185"xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/title | "Functional analysis of an archaebacterial voltage-dependent K+ channel."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/title | "Functional analysis of an archaebacterial voltage-dependent K+ channel."xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/volume | "422"xsd:string |
| http://purl.uniprot.org/citations/12629550 | http://purl.uniprot.org/core/volume | "422"xsd:string |