| http://purl.uniprot.org/citations/12631284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12631284 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1 (IL-1) induces multiple genes via activation of transcription factors that include NF-kappa B and activator protein-1 (AP-1). We found that IL-1-mediated c-Src activation was required for AP-1 activation, but not for NF-kappa B activation and also revealed that c-Src-induced AP-1 activation was enhanced synergistically by the coexpression of TNF receptor associated factor 6 (TRAF6). In addition, c-Src interacts with TRAF6 in response to IL-1 and this interaction is required for c-Src activity. However, neither dominant negative mutants of TRAF6 (TRAF6 DN) nor kinase-dead mutant of c-Src (c-Src KD) counteracted each-induced AP-1 activation, suggesting no hierarchy between these two molecules. During the TRAF6 and c-Src-induced AP-1 activation, phosphatidylinositol 3 (PI3)-kinase, its downstream signaling molecule, Akt and c-Jun N-terminal kinase (JNK) were significantly activated and inhibition of these kinase activities down-regulated AP-1 activation through the suppression of c-fos expression. Furthermore, TRAF6 and c-Src-induced JNK activation was significantly inhibited by PI3-kinase inhibitor or a dominant negative mutant of Akt (Akt DN). Taken together, our results demonstrate that c-Src and TRAF6 are key mediators of IL-1-induced AP-1 activation and provide evidence of cross talk between c-Src and TRAF6 molecules through PI3 kinase-Akt-JNK pathways."xsd:string |
| http://purl.uniprot.org/citations/12631284 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1432-1033.2003.03487.x"xsd:string |
| http://purl.uniprot.org/citations/12631284 | http://purl.uniprot.org/core/author | "Sonoda Y."xsd:string |
| http://purl.uniprot.org/citations/12631284 | http://purl.uniprot.org/core/author | "Kasahara T."xsd:string |
| http://purl.uniprot.org/citations/12631284 | http://purl.uniprot.org/core/author | "Tago K."xsd:string |
| http://purl.uniprot.org/citations/12631284 | http://purl.uniprot.org/core/author | "Tominaga S."xsd:string |
| http://purl.uniprot.org/citations/12631284 | http://purl.uniprot.org/core/author | "Funakoshi-Tago M."xsd:string |
| http://purl.uniprot.org/citations/12631284 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12631284 | http://purl.uniprot.org/core/name | "Eur J Biochem"xsd:string |
| http://purl.uniprot.org/citations/12631284 | http://purl.uniprot.org/core/pages | "1257-1268"xsd:string |
| http://purl.uniprot.org/citations/12631284 | http://purl.uniprot.org/core/title | "TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway."xsd:string |
| http://purl.uniprot.org/citations/12631284 | http://purl.uniprot.org/core/volume | "270"xsd:string |
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