| http://purl.uniprot.org/citations/12637671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12637671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12637671 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily share an intracytoplasmic Toll-IL-1 receptor (TIR) domain, which mediates recruitment of the interleukin-1 receptor-associated kinase (IRAK) complex via TIR-containing adapter molecules. We describe three unrelated children with inherited IRAK-4 deficiency. Their blood and fibroblast cells did not activate nuclear factor kappaB and mitogen-activated protein kinase (MAPK) and failed to induce downstream cytokines in response to any of the known ligands of TIR-bearing receptors. The otherwise healthy children developed infections caused by pyogenic bacteria. These findings suggest that, in humans, the TIR-IRAK signaling pathway is crucial for protective immunity against specific bacteria but is redundant against most other microorganisms."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1081902"xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1081902"xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Yang K."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Yang K."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Ozinsky A."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Ozinsky A."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Rucker R."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Rucker R."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Bustamante J."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Bustamante J."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Davies G."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Davies G."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Bonnet M."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Bonnet M."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Picard C."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Picard C."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Day N.K."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Day N.K."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Good R.A."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Good R.A."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Puel A."xsd:string |
| http://purl.uniprot.org/citations/12637671 | http://purl.uniprot.org/core/author | "Puel A."xsd:string |