| http://purl.uniprot.org/citations/12638230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12638230 | http://www.w3.org/2000/01/rdf-schema#comment | "The gracile axonal dystrophy (gad) mice are known to have a deletion within the gene encoding ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) and show hereditary sensory deterioration and motor paresis. Expression of Uch-L1 is reported to be almost limited to the nervous system and testis. To understand whether Uch-L1, one of the major ubiquitin carboxy-terminal hydrolase (UCH) isozymes in the testis, affects spermatogenesis and other UCH isozymes (Uch-L3, L4 and L5) expression in the testis, we compared the testis between gad, hetero and wild type mice by histological, immunohistochemical analyses and RT-PCR. Histological analysis in 25-week-old gad mice showed shrinking of seminiferous tubules, decreasing total number of cells and enlargement of remaining cells in seminiferous tubules. By immunohistochemistry, a significant decrease (p < 0.05) in the number of proliferating cell nuclear antigen (PCNA) positive cells was observed. Expression of other UCH isozyme mRNAs was not apparently affected by Uch-L1 deficiency in 25-week-old gad mice. This study is the first report on the testis of gad mutant mouse."xsd:string |
| http://purl.uniprot.org/citations/12638230 | http://purl.org/dc/terms/identifier | "doi:10.1538/expanim.52.1"xsd:string |
| http://purl.uniprot.org/citations/12638230 | http://purl.uniprot.org/core/author | "Ishii Y."xsd:string |
| http://purl.uniprot.org/citations/12638230 | http://purl.uniprot.org/core/author | "Kikuchi T."xsd:string |
| http://purl.uniprot.org/citations/12638230 | http://purl.uniprot.org/core/author | "Yoshikawa Y."xsd:string |
| http://purl.uniprot.org/citations/12638230 | http://purl.uniprot.org/core/author | "Kwon J."xsd:string |
| http://purl.uniprot.org/citations/12638230 | http://purl.uniprot.org/core/author | "Kyuwa S."xsd:string |
| http://purl.uniprot.org/citations/12638230 | http://purl.uniprot.org/core/author | "Setsuie R."xsd:string |
| http://purl.uniprot.org/citations/12638230 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12638230 | http://purl.uniprot.org/core/name | "Exp Anim"xsd:string |
| http://purl.uniprot.org/citations/12638230 | http://purl.uniprot.org/core/pages | "1-9"xsd:string |
| http://purl.uniprot.org/citations/12638230 | http://purl.uniprot.org/core/title | "Characterization of the testis in congenitally ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) defective (gad) mice."xsd:string |
| http://purl.uniprot.org/citations/12638230 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/12638230 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12638230 |
| http://purl.uniprot.org/citations/12638230 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12638230 |
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