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| http://purl.uniprot.org/citations/12639247 | http://www.w3.org/2000/01/rdf-schema#comment | "Human immunodeficiency virus type 1 (HIV-1) alters gene expression in infected cells, leading to cellular dysfunction. We uncovered a number of host cell genes that are modulated in both CD4(+) T cell lines and primary CD4(+) T lymphocytes infected with HIV-1, using high-density oligonucleotide probe microarray technology. We focused on one gene in particular, nuclear factor I-B2 (NFI-B2), because of its high level of expression. NFI-B2 is a member of the nuclear factor I family of nuclear proteins, which are known to be involved in viral and cellular transcription. To better understand the role of NFI-B2 during HIV-1 infection, we generated a Jurkat T cell line that constitutively expressed NFI-B2. After infection with HIV-1, these cells produced fewer viruses because of a downregulation of surface CD4 expression. The surface expression of the coreceptor, CXCR4, remained unchanged. Furthermore, levels of CD4 mRNA were reduced in NFI-B2-producing cells, suggesting that expression of NFI-B2 impairs CD4 transcription. Modulation of NFI-B2 by HIV-1 may represent yet another mechanism by which HIV infection reduces cell surface expression of CD4."xsd:string |
| http://purl.uniprot.org/citations/12639247 | http://purl.org/dc/terms/identifier | "doi:10.1089/088922203762688621"xsd:string |
| http://purl.uniprot.org/citations/12639247 | http://purl.uniprot.org/core/author | "Du P."xsd:string |
| http://purl.uniprot.org/citations/12639247 | http://purl.uniprot.org/core/author | "Corbeil J."xsd:string |
| http://purl.uniprot.org/citations/12639247 | http://purl.uniprot.org/core/author | "Richman D."xsd:string |
| http://purl.uniprot.org/citations/12639247 | http://purl.uniprot.org/core/author | "Rought S."xsd:string |
| http://purl.uniprot.org/citations/12639247 | http://purl.uniprot.org/core/author | "Sheeter D."xsd:string |
| http://purl.uniprot.org/citations/12639247 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12639247 | http://purl.uniprot.org/core/name | "AIDS Res Hum Retroviruses"xsd:string |
| http://purl.uniprot.org/citations/12639247 | http://purl.uniprot.org/core/pages | "117-123"xsd:string |
| http://purl.uniprot.org/citations/12639247 | http://purl.uniprot.org/core/title | "Surface CD4 expression modulated by a cellular factor induced by HIV type 1 infection."xsd:string |
| http://purl.uniprot.org/citations/12639247 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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