| http://purl.uniprot.org/citations/12639765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12639765 | http://www.w3.org/2000/01/rdf-schema#comment | "Association of the NEUROD Ala45Thr polymorphism with Type 1 diabetes mellitus (DM) has been found in some but not all populations. We performed a study on the association of two NEUROD exon 2 polymorphisms, the Ala45Thr and the Pro197His, with childhood-onset Type 1 DM in the Czech population. We compared 285 children with Type 1 DM diagnosed under the age of 15 years with 289 non-diabetic control children. The genotypes were determined using novel real-time allele-specific PCR assays in the TaqMan format, and data were analysed using logistic regression. The numbers of subjects with codon 45 genotypes Ala/Ala, Ala/Thr, Thr/Thr were 95, 145, 45 among cases and 117, 130, 42 among controls. Thr45 phenotypic positivity was associated with a significant risk of Type 1 DM (OR=2.01, CI 95% 1.25-3.24) in a multivariate logistic regression model involving also the insulin gene -23HphI genotype and the presence of Type 1 DM-associated HLA-DQB1*0302-DQA1*03 (DQ8) and DQB1*0201-DQA1*05 (DQ2) molecules. No association was observed for the Pro197His mutation which was carried by 5.3% cases and 5.9% controls. Our results confirm that the NEUROD Ala45Thr polymorphism is associated with childhood-onset Type 1 DM."xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0168-8227(02)00251-6"xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/author | "Cinek O."xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/author | "Sumnik Z."xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/author | "Bendlova B."xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/author | "Drevinek P."xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/author | "Kolouskova S."xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/author | "Snajderova M."xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/author | "Vavrinec J."xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/author | "Sedlakova P."xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/name | "Diabetes Res Clin Pract"xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/pages | "49-56"xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/title | "NEUROD polymorphism Ala45Thr is associated with Type 1 diabetes mellitus in Czech children."xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://purl.uniprot.org/core/volume | "60"xsd:string |
| http://purl.uniprot.org/citations/12639765 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12639765 |
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