| http://purl.uniprot.org/citations/12640123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12640123 | http://www.w3.org/2000/01/rdf-schema#comment | "The adapter SLP-76 plays an essential role in Fc epsilon RI signaling, since SLP-76(-/-) bone marrow-derived mast cells (BMMC) fail to degranulate and release interleukin-6 (IL-6) following Fc epsilon RI ligation. To define the role of SLP-76 domains and motifs in Fc epsilon RI signaling, SLP-76(-/-) BMMC were retrovirally transduced with SLP-76 and SLP-76 mutants. The SLP-76 N-terminal and Gads binding domains, but not the SH2 domain, were critical for Fc epsilon RI-mediated degranulation and IL-6 secretion, whereas all three domains are essential for T-cell proliferation following T-cell receptor (TCR) ligation. Unexpectedly, the three tyrosine residues in SLP-76 critical for TCR signaling, Y112, Y128, and Y145, were not essential for IL-6 secretion, but were required for degranulation and mitogen-activated protein kinase activation. Furthermore, a Y112/128F SLP-76 mutant, but not a Y145F mutant, strongly reconstituted mast cell degranulation, suggesting a critical role for Y145 in Fc epsilon RI-mediated exocytosis. These results point to important differences in the function of SLP-76 between T cells and mast cells."xsd:string |
| http://purl.uniprot.org/citations/12640123 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.7.2395-2406.2003"xsd:string |
| http://purl.uniprot.org/citations/12640123 | http://purl.uniprot.org/core/author | "Lee J.S."xsd:string |
| http://purl.uniprot.org/citations/12640123 | http://purl.uniprot.org/core/author | "Kumar L."xsd:string |
| http://purl.uniprot.org/citations/12640123 | http://purl.uniprot.org/core/author | "Kettner A."xsd:string |
| http://purl.uniprot.org/citations/12640123 | http://purl.uniprot.org/core/author | "Mulligan R."xsd:string |
| http://purl.uniprot.org/citations/12640123 | http://purl.uniprot.org/core/author | "Geha R.S."xsd:string |
| http://purl.uniprot.org/citations/12640123 | http://purl.uniprot.org/core/author | "Falet H."xsd:string |
| http://purl.uniprot.org/citations/12640123 | http://purl.uniprot.org/core/author | "Pivniouk V."xsd:string |
| http://purl.uniprot.org/citations/12640123 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12640123 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12640123 | http://purl.uniprot.org/core/pages | "2395-2406"xsd:string |
| http://purl.uniprot.org/citations/12640123 | http://purl.uniprot.org/core/title | "Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells."xsd:string |
| http://purl.uniprot.org/citations/12640123 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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