| http://purl.uniprot.org/citations/12642601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12642601 | http://www.w3.org/2000/01/rdf-schema#comment | "Highly polarized type 2 cytokine responses can be harmful and even lethal to the host if they are too vigorous or persist too long. Therefore, it is important to elucidate the mechanisms that down-regulate these reactions. Interleukin (IL)-13 has emerged as a central mediator of T helper cell (Th)2-dominant immune responses, exhibiting a diverse array of functional activities including regulation of airway hyperreactivity, resistance to nematode parasites, and tissue remodeling and fibrosis. Here, we show that IL-13 receptor (R)alpha2 is a critical down-regulatory factor of IL-13-mediated tissue fibrosis induced by the parasitic helminth Schistosoma mansoni. IL-13Ralpha2 expression was induced after the onset of the fibrotic response, IL-10, IL-13, and Stat6 dependent, and inhibited by the Th1-inducing adjuvant IL-12. Strikingly, schistosome-infected C57BL/6 and BALB/c IL-13Ralpha2-deficient mice showed a marked exacerbation in hepatic fibrosis, despite displaying no change in granuloma size, tissue eosinophilia, or mastocytosis. Fibrosis increased despite the fact that IL-13 levels decreased significantly in the liver and serum. Importantly, pathology was prevented when IL-13Ralpha2-deficient mice were treated with a soluble IL-13Ralpha2-Fc construct, formally demonstrating that their exacerbated fibrotic response was due to heightened IL-13 activity. Together, these studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20020903"xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/author | "Collins M."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/author | "Wong A."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/author | "Cheever A.W."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/author | "Wynn T.A."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/author | "Whitters M.J."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/author | "Grusby M.J."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/author | "Donaldson D.D."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/author | "Mentink-Kane M."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/author | "Jacobson B.A."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/author | "Goad M.E."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/author | "Chiaramonte M.G."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/pages | "687-701"xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/title | "Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response."xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://purl.uniprot.org/core/volume | "197"xsd:string |
| http://purl.uniprot.org/citations/12642601 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12642601 |
| http://purl.uniprot.org/citations/12642601 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12642601 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-12642601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12642601 |
| http://purl.uniprot.org/uniprot/#_O88786-mappedCitation-12642601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12642601 |
| http://purl.uniprot.org/uniprot/#_G3UXB0-mappedCitation-12642601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12642601 |
| http://purl.uniprot.org/uniprot/#_P07750-mappedCitation-12642601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12642601 |