| http://purl.uniprot.org/citations/12646168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12646168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12646168 | http://www.w3.org/2000/01/rdf-schema#comment | "ASC is a pro-apoptotic protein containing a pyrin domain (PD) and a caspase-recruitment domain (CARD). A previous study suggests that ASC interacts with Ipaf, a member of the Apaf-1/Nod1 protein family. However, the functional relevance of the interaction has not been determined. Here, we report that co-expression of ASC with Ipaf or oligomerization of ASC induces both apoptosis and NF-kappa B activation. Apoptosis induced through ASC was inhibited by a mutant form of Caspase-8 but not by that of Caspase-1. The PD of ASC physically interacted with Caspase-8 as well as with pyrin, the familial Mediterranean fever gene product. Caspase-8 deficiency rescued mouse fibroblasts from apoptosis induced by ASC oligomerization. Pyrin disrupted the interaction between ASC and Caspase-8, and inhibited both apoptosis and NF-kappa B activation induced by ASC. These findings suggest that ASC is a mediator of NF-kappa B activation and Caspase-8-dependent apoptosis in an Ipaf signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00309-7"xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00309-7"xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Ogura Y."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Ogura Y."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Inohara N."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Inohara N."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Katsuyama T."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Katsuyama T."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Masumoto J."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Masumoto J."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Taniguchi S."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Taniguchi S."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Chen F.F."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Chen F.F."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Gumucio D.L."xsd:string |
| http://purl.uniprot.org/citations/12646168 | http://purl.uniprot.org/core/author | "Gumucio D.L."xsd:string |