| http://purl.uniprot.org/citations/12646186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12646186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12646186 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcriptional regulatory protein HSF1 is the key mediator of induced heat shock protein gene expression in response to elevated temperature and other stresses. Our previous studies identified stress-induced SUMO-1 modification of HSF1 as an important regulator of the DNA-binding activity of this factor. The underlying molecular mechanism by which stress leads to sumoylation of HSF1 was unknown. Prompted by previous studies indicating stress-induced phosphorylation at serine 307 of HSF1, a site very near the sumoylation site at lysine 298, we examined the role of this phosphorylation event in regulating SUMO-1 modification of HSF1. Using a combination of transfection and in vitro phosphorylation/sumoylation experiments, our results indicate that phosphorylation at serine 307 stimulates sumoylation of HSF1. Our results also reveal a role for a conserved leucine zipper sequence in the C-terminal region of HSF1 in inhibiting its SUMO-1 modification. Based on these data, we postulate that phosphorylation at serine 307 could stimulate HSF1 sumoylation by causing a conformation change that relieves the inhibitory effect of the C-terminal leucine zipper."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00312-7"xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00312-7"xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/author | "Hong Y."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/author | "Hong Y."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/author | "Sarge K.D."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/author | "Sarge K.D."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/author | "Hilgarth R.S."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/author | "Hilgarth R.S."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/author | "Park-Sarge O.K."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/author | "Park-Sarge O.K."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/pages | "196-200"xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/pages | "196-200"xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/title | "Insights into the regulation of heat shock transcription factor 1 SUMO-1 modification."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/title | "Insights into the regulation of heat shock transcription factor 1 SUMO-1 modification."xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/volume | "303"xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://purl.uniprot.org/core/volume | "303"xsd:string |
| http://purl.uniprot.org/citations/12646186 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12646186 |
| http://purl.uniprot.org/citations/12646186 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12646186 |