| http://purl.uniprot.org/citations/12646194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12646194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12646194 | http://www.w3.org/2000/01/rdf-schema#comment | "Lectin-like oxidized low-density lipoprotein receptor (LOX-1/OLR1) has been suggested to play a role in the progression of atherogenesis. We analyzed the OLR1 gene and found a single nucleotide polymorphism (SNP), G501C, in patients with ischemic heart disease from a single family, which resulted in the missense mutation of K167N in LOX-1 protein. We compared the group of patients with myocardial infarction (MI) (n=102) with a group of clinically healthy subjects (n=102), and found that the MI group had a significantly high frequency of 501G/C+501C/C (38.2%) compared with the healthy group (17.6%; p<0.002). The odds ratio for the risk of MI associated with the 501G/C+501C/C genotype was 2.89 (95% CI, 1.51-5.53). These findings suggest that OLR1 or a neighboring gene linked with G501C SNP is important for the incidence of MI. Manipulating LOX-1 activity might be a useful therapeutic and preventative approach for coronary artery disease, especially for individuals with the G501C genotype of OLR1."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00326-7"xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00326-7"xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Masaki T."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Masaki T."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Imamura S."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Imamura S."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Furutani M."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Furutani M."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Kasanuki H."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Kasanuki H."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Furutani Y."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Furutani Y."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Matsuoka R."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Matsuoka R."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Sawamura T."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Sawamura T."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Kawana M."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Kawana M."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Hinagata J."xsd:string |
| http://purl.uniprot.org/citations/12646194 | http://purl.uniprot.org/core/author | "Hinagata J."xsd:string |