| http://purl.uniprot.org/citations/12646221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12646221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12646221 | http://www.w3.org/2000/01/rdf-schema#comment | "Disabled-1 (Dab1) is a cytosolic adaptor protein that plays critical roles in cortical development. However, a detailed mechanism of action has not yet been clearly defined. Through yeast two-hybrid screening, we observed that mouse Siah-1A, an E3 ubiquitin ligase containing a RING finger motif, interacts with Dab1. Co-immunoprecipitation experiments and in vitro binding experiments both indicated direct interaction between Siah and Dab1. Steady-state expression of Siah was enhanced by the presence of Dab1 or lactacystin, a representative proteasomal inhibitor. Auto-ubiquitination of Siah was inhibited by the presence of Dab1, suggesting inhibition of Siah activity and subsequent increase of Siah expression by Dab1. Both Dab1-induced increase of steady-state expression of Deleted in colorectal cancer (DCC), one of the well-known substrates of Siah, and its inhibition by Siah Delta R suggest that Dab1 increases expression of DCC through inhibiting the activity of endogenous Siah. Our results suggest that Dab1 inhibits the activity of Siah."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00247-x"xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00247-x"xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/author | "Ohshima T."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/author | "Ohshima T."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/author | "Watanabe N."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/author | "Watanabe N."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/author | "Mikoshiba K."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/author | "Mikoshiba K."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/author | "Nukina N."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/author | "Nukina N."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/author | "Hamanaka H."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/author | "Hamanaka H."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/author | "Park T.-J."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/author | "Park T.-J."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/pages | "671-678"xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/pages | "671-678"xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/title | "Inhibition of ubiquitin ligase Siah-1A by disabled-1."xsd:string |
| http://purl.uniprot.org/citations/12646221 | http://purl.uniprot.org/core/title | "Inhibition of ubiquitin ligase Siah-1A by disabled-1."xsd:string |