| http://purl.uniprot.org/citations/12646235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12646235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12646235 | http://www.w3.org/2000/01/rdf-schema#comment | "We have reported on Spred-1 and Spred-2, which inhibit MAP kinase activation by interacting with c-kit and ras/raf. Here, we report the cloning of a third member in this family, Spred-3. Spred-3 is expressed exclusively in the brain and its gene locates in chromosome 19q13.13 in human. Like Spred-1 and -2, Spred-3 contains an EVH1 domain in the N-terminus and a Sprouty-related cysteine-rich region (SPR domain) in the C-terminus that is necessary for membrane localization. However, Spred-3 does not possess a functional c-kit binding domain (KBD), since the critical amino acid Arg residue in this region was replaced with Gly in Spred-3. Although Spred-3 suppressed growth factor-induced MAP kinase (Erk) activation, inhibitory activity of Spred-3 was lower than that of Spred-1 or Spred-2. By the analysis of chimeric molecules between Spred-3 and Spred-1, we found that the SPR domain, rather than KBD, is responsible for efficient Erk suppression. The finding of Spred-3 revealed the presence of a novel family of regulators for the Ras/MAP kinase pathway, each member of which may have different specificities for extracellular signals."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00259-6"xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00259-6"xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Matsuda Y."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Matsuda Y."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Kato R."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Kato R."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Kuroiwa A."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Kuroiwa A."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Wakioka T."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Wakioka T."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Nonami A."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Nonami A."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Taketomi T."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/author | "Taketomi T."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/pages | "767-772"xsd:string |
| http://purl.uniprot.org/citations/12646235 | http://purl.uniprot.org/core/pages | "767-772"xsd:string |