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http://purl.uniprot.org/citations/12646494http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12646494http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12646494http://www.w3.org/2000/01/rdf-schema#comment"Differential display in combination with a cDNA cloning approach were used to isolate a novel gene, spergen-2, which has an open reading frame of 1500 nucleotides and encodes a protein of 500 amino acids that contains ankyrin repeat motifs and a putative nuclear localization signal. Expression of spergen-2 is developmentally upregulated in testis. In situ hybridization revealed that spergen-2 mRNA is expressed in spermatocytes and round spermatids (steps 1-6). Immunohistochemical analysis with confocal laser-scanning microscopy demonstrated that spergen-2 protein is predominantly expressed in nuclei of late spermatocytes (stages IX-XIV) and spermatids (steps 1-11), indicating the restricted expression of spergen-2 during spermatogenesis. In nucleoplasm of spermatogenic cell nuclei, spergen-2 tends to localize in the interchromosome space with relatively low DNA density. These findings indicate a potential role of spergen-2 in spermatogenesis, especially in cell differentiation from late pachytene spermatocytes to spermatids or in early spermatid differentiation."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.org/dc/terms/identifier"doi:10.1095/biolreprod.102.013987"xsd:string
http://purl.uniprot.org/citations/12646494http://purl.org/dc/terms/identifier"doi:10.1095/biolreprod.102.013987"xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/author"Mori T."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/author"Mori T."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/author"Shibata Y."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/author"Shibata Y."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/author"Iida H."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/author"Iida H."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/author"Toshimori K."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/author"Toshimori K."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/author"Doiguchi M."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/author"Doiguchi M."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/author"Urasoko A."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/author"Urasoko A."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/name"Biol. Reprod."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/name"Biol Reprod"xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/pages"421-429"xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/pages"421-429"xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/title"Complementary DNA cloning and characterization of rat spergen-2, a spermatogenic cell-specific gene 2 encoding a 56-kilodalton nuclear protein bearing ankyrin repeat motifs."xsd:string
http://purl.uniprot.org/citations/12646494http://purl.uniprot.org/core/title"Complementary DNA cloning and characterization of rat spergen-2, a spermatogenic cell-specific gene 2 encoding a 56-kilodalton nuclear protein bearing ankyrin repeat motifs."xsd:string