| http://purl.uniprot.org/citations/12648213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12648213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12648213 | http://www.w3.org/2000/01/rdf-schema#comment | "Desmosomes are essential adhesion structures in most epithelia that link the intermediate filament network of one cell to its neighbor, thereby forming a strong bond. The molecular components of desmosomes belong to the cadherin superfamily, the plakin family, and the armadillo repeat protein family. The desmosomal cadherins are calcium-dependent transmembrane adhesion molecules and comprise the desmogleins and desmocollins. To date, three human desmoglein isoforms have been characterized, namely desmogleins 1, 2, and 3 that are expressed in a tissue- and differentiation-specific manner. Here we have identified and characterized, at the genetic level, a novel human desmoglein cDNA sharing homology with desmogleins 1, 2, 3 and we name this desmoglein 4. The human desmoglein 4 cDNA (3.6 kb) contains an open reading frame of 3120 bp that encodes a precursor protein of 1040 amino acids. The predicted mature protein comprises 991 amino acids with a molecular weight of 107822 Da at pI 4.38. Human desmoglein 4 shares 41% identity with human desmoglein 1, 37% with human desmoglein 2, and 50% with human desmoglein 3. Analysis of the exon/intron organization of the human desmoglein 4 gene (DSG4) demonstrates that it is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 and DSG3. We have demonstrated using RT-PCR on multiple tissue cDNA samples that desmoglein 4 has very specific tissue expression in salivary gland, testis, prostate, and skin."xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1523-1747.2003.12113.x"xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1523-1747.2003.12113.x"xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/author | "Whittock N.V."xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/author | "Whittock N.V."xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/author | "Bower C."xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/author | "Bower C."xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/name | "J. Invest. Dermatol."xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/name | "J. Invest. Dermatol."xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/pages | "523-530"xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/pages | "523-530"xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/title | "Genetic evidence for a novel human desmosomal cadherin, desmoglein 4."xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/title | "Genetic evidence for a novel human desmosomal cadherin, desmoglein 4."xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/12648213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12648213 |
| http://purl.uniprot.org/citations/12648213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12648213 |
| http://purl.uniprot.org/citations/12648213 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12648213 |
| http://purl.uniprot.org/citations/12648213 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12648213 |
| http://purl.uniprot.org/uniprot/Q86SJ6 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12648213 |
| http://purl.uniprot.org/uniprot/#_kb.Q86SJ6_up.isolatedFrom_tissue.1030 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12648213 |