| http://purl.uniprot.org/citations/12649209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12649209 | http://www.w3.org/2000/01/rdf-schema#comment | "By means of the yeast two-hybrid system, we have discovered a novel physical interaction between the adenovirus E1A oncoprotein and Ran, a small GTPase which regulates nucleocytoplasmic transport, cell cycle progression, and mitotic spindle organization. Expression of E1A elicits induction of S phase and centrosome amplification in a variety of rodent cell lines. The induction of supernumerary centrosomes requires functional RCC1, the nucleotide exchange factor for Ran and, hence, a functional Ran network. The E1A portion responsible for the interaction with Ran is the extreme NH(2)-terminal region (amino acids 1-36), which is also required for the induction of centrosome amplification. In an in vitro assay with recombinant proteins, wild-type E1A interferes with nucleotide exchange on Ran, whereas an E1A mutant, deleted from the extreme NH(2)-terminal region, does not. In addition, we detected an in vitro interaction between Ran and HPV-16 E7 and SV40 large T antigen, two oncoproteins functionally related to E1A. These findings suggest a common pathway of these oncoproteins in eliciting virus-induced genomic instability."xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/author | "Mileo A.M."xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/author | "De Luca A."xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/author | "Baldi A."xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/author | "Lavia P."xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/author | "Palena A."xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/author | "Paggi M.G."xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/author | "Severino A."xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/author | "Malquori L."xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/author | "Mangiacasale R."xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/pages | "1430-1437"xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/title | "E1A deregulates the centrosome cycle in a Ran GTPase-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/12649209 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12649209 |
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