| http://purl.uniprot.org/citations/12650609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12650609 | http://www.w3.org/2000/01/rdf-schema#comment | "Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-I inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-I mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells."xsd:string |
| http://purl.uniprot.org/citations/12650609 | http://purl.org/dc/terms/identifier | "doi:10.1023/a:1022598604565"xsd:string |
| http://purl.uniprot.org/citations/12650609 | http://purl.uniprot.org/core/author | "Huang C.Y."xsd:string |
| http://purl.uniprot.org/citations/12650609 | http://purl.uniprot.org/core/author | "Lee Y.C."xsd:string |
| http://purl.uniprot.org/citations/12650609 | http://purl.uniprot.org/core/author | "Yang P.C."xsd:string |
| http://purl.uniprot.org/citations/12650609 | http://purl.uniprot.org/core/author | "Hong T.M."xsd:string |
| http://purl.uniprot.org/citations/12650609 | http://purl.uniprot.org/core/author | "Shih J.Y."xsd:string |
| http://purl.uniprot.org/citations/12650609 | http://purl.uniprot.org/core/author | "Yang S.C."xsd:string |
| http://purl.uniprot.org/citations/12650609 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12650609 | http://purl.uniprot.org/core/name | "Clin Exp Metastasis"xsd:string |
| http://purl.uniprot.org/citations/12650609 | http://purl.uniprot.org/core/pages | "69-76"xsd:string |
| http://purl.uniprot.org/citations/12650609 | http://purl.uniprot.org/core/title | "Collapsin response mediator protein-1: a novel invasion-suppressor gene."xsd:string |
| http://purl.uniprot.org/citations/12650609 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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