| http://purl.uniprot.org/citations/12650940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12650940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12650940 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously described a partial cDNA sequence encoding a RhoGAP protein, GAP25 that is homologous to the recently reported ArhGAP9 and ArhGAP12. We now describe a related new member ArhGAP15 that shares a number of domain similarities, including a pleckstrin homology (PH) domain, a RhoGAP domain and a novel motif N-terminal to the GAP domain. This novel motif was found to be responsible for nucleotide-independent Rac1 binding. Using swop mutants of Rac/Cdc42, we have established that the binding is through the C-terminal half of Rac1. The GAP domain of ArhGAP15 showed specificity towards Rac1 in vitro. The PH domain is required for ArhGAP15 to localize to cell periphery and over-expression of the full-length ArhGAP15, but not the mutant with a partial deletion of the PH domain, resulted in an increase in actin stress fibers and cell contraction. These morphological effects can be attenuated by the co-expression of dominant negative Rac1(N17). HeLa cells expressing ArhGAP15 were also resistant to phorbol myristatate acetate treatment, suggesting that ArhGAP15 is a potential regulator of Rac1."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(03)00213-8"xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(03)00213-8"xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/author | "Lim L."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/author | "Lim L."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/author | "Leung T."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/author | "Leung T."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/author | "Yong J."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/author | "Yong J."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/author | "Ng C.H."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/author | "Ng C.H."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/author | "Seoh M.L."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/author | "Seoh M.L."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/pages | "131-137"xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/pages | "131-137"xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/title | "ArhGAP15, a novel human RacGAP protein with GTPase binding property."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/title | "ArhGAP15, a novel human RacGAP protein with GTPase binding property."xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/volume | "539"xsd:string |
| http://purl.uniprot.org/citations/12650940 | http://purl.uniprot.org/core/volume | "539"xsd:string |