| http://purl.uniprot.org/citations/12651892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12651892 | http://www.w3.org/2000/01/rdf-schema#comment | "The T-box transcription factor Tpit was identified as a cell-specific factor for expression of the pituitary proopiomelanocortin (POMC) gene. Expression of this factor is exclusively restricted to the pituitary POMC-expressing lineages, the corticotrophs and melanotrophs. We have now determined the role of this factor in pituitary cell differentiation. Tpit is a positive regulator for late POMC cell differentiation and POMC expression, but it is not essential for lineage commitment. The pituitary intermediate lobe normally contains only Tpit-expressing melanotrophs. Inactivation of the Tpit gene results in almost complete loss of POMC-expressing cells in this tissue, which now has a large number of gonadotrophs and a few clusters of Pit-1-independent thyrotrophs. The role of Tpit as a negative regulator of gonadotroph differentiation was confirmed in transgenic gain-of-function experiments. One mechanism to account for the negative role of Tpit in differentiation may be trans-repression between Tpit and the gonadotroph-restricted factor SF1. These data suggest that antagonism between Tpit and SF1 may play a role in establishment of POMC and gonadotroph lineages and that these lineages may arise from common precursors."xsd:string |
| http://purl.uniprot.org/citations/12651892 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1065703"xsd:string |
| http://purl.uniprot.org/citations/12651892 | http://purl.uniprot.org/core/author | "Drouin J."xsd:string |
| http://purl.uniprot.org/citations/12651892 | http://purl.uniprot.org/core/author | "Couture C."xsd:string |
| http://purl.uniprot.org/citations/12651892 | http://purl.uniprot.org/core/author | "Gauthier Y."xsd:string |
| http://purl.uniprot.org/citations/12651892 | http://purl.uniprot.org/core/author | "Vallette-Kasic S."xsd:string |
| http://purl.uniprot.org/citations/12651892 | http://purl.uniprot.org/core/author | "Tsai J.P."xsd:string |
| http://purl.uniprot.org/citations/12651892 | http://purl.uniprot.org/core/author | "Pulichino A.M."xsd:string |
| http://purl.uniprot.org/citations/12651892 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12651892 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/12651892 | http://purl.uniprot.org/core/pages | "738-747"xsd:string |
| http://purl.uniprot.org/citations/12651892 | http://purl.uniprot.org/core/title | "Tpit determines alternate fates during pituitary cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/12651892 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/12651892 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12651892 |
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