| http://purl.uniprot.org/citations/12651923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12651923 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the human SLC26A3 gene, also known as down-regulated in adenoma (hDRA), cause autosomal recessive congenital chloride-losing diarrhoea (CLD). hDRA expressed in Xenopus oocytes mediated bidirectional Cl--Cl- and Cl--HCO3-exchange. In contrast, transport of oxalate was low, and transport of sulfate and of butyrate was undetectable. Two CLD missense disease mutants of hDRA were nonfunctional in oocytes. Truncation of up to 44 C-terminal amino acids from the putatively cytoplasmic C-terminal hydrophilic domain left transport function unimpaired, but deletion of the adjacent STAS (sulfate transporter anti-sigma factor antagonist) domain abolished function. hDRA-mediated Cl-transport was insensitive to changing extracellular pH, but was inhibited by intracellular acidification and activated by NH4+ at acidifying concentrations. These regulatory responses did not require the presence of either hDRA's N-terminal cytoplasmic tail or its 44 C-terminal amino acids, but they did require more proximate residues of the C-terminal cytoplasmic domain. Although only weakly sensitive to inhibition by stilbenes, hDRA was inhibited with two orders of magnitude greater potency by the anti-inflammatory drugs niflumate and tenidap. cAMP-insensitive Cl--HCO3-exchange mediated by hDRA gained modest cAMP sensitivity when co-expressed with cystic fibrosis transmembrane conductance regulator (CFTR). Despite the absence of hDRA transcripts in human cell lines derived from CFTR patients, DRA mRNA was present at wild-type levels in proximal colon and nearly so in the distal ileum of CFTR(-/-) mice. Thus, pharmacological modulation of DRA might be a useful adjunct treatment of cystic fibrosis."xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.org/dc/terms/identifier | "doi:10.1113/jphysiol.2003.039818"xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/author | "Jiang L."xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/author | "Stewart A.K."xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/author | "Alper S.L."xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/author | "Shmukler B.E."xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/author | "Schweinfest C.W."xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/author | "Blanco P."xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/author | "Freedman S.D."xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/author | "Chernova M.N."xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/name | "J Physiol"xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/pages | "3-19"xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/title | "Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes."xsd:string |
| http://purl.uniprot.org/citations/12651923 | http://purl.uniprot.org/core/volume | "549"xsd:string |
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