| http://purl.uniprot.org/citations/12652296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12652296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12652296 | http://www.w3.org/2000/01/rdf-schema#comment | "Src kinase-associated phosphoprotein of 55 kDa (SKAP-55; encoded by SCAP1) is a T cell adaptor protein of unknown function that contains a pleckstrin homology and an SH3 domain. Here we show that SKAP-55 regulates integrin-mediated adhesion and conjugate formation between T cells and antigen-presenting cells (APCs). SKAP-55 enhances adhesion to fibronectin and intercellular adhesion molecule-1 (ICAM-1), colocalizes with actin at the T cell-APC synapse and promotes the clustering of lymphocyte-associated antigen-1 (LFA-1). Enhanced conjugation is comparable to that induced by adhesion and degranulation-promoting adaptor protein (ADAP), a binding partner of SKAP-55, and is abrogated by deletion of the SKAP-55 SH3 domain. Conjugate formation is accompanied by the translocation of SKAP-55 to membrane rafts, an event that is regulated by both LFA-1 and T cell receptor ligation. Our findings identify a mechanism by which SKAP-55 modulates T cell responses to antigen."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni913"xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni913"xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Smith A."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Smith A."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Schneider H."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Schneider H."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Rudd C.E."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Rudd C.E."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Hogg N."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Hogg N."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Azouz A."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Azouz A."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Moon E.-Y."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/author | "Moon E.-Y."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12652296 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |