| http://purl.uniprot.org/citations/12654248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12654248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12654248 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00158-2"xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00158-2"xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Anderson D.A."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Anderson D.A."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Bevan S."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Bevan S."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Jegla T."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Jegla T."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "McIntyre P."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "McIntyre P."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Patapoutian A."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Patapoutian A."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Hwang S.W."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Hwang S.W."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Mosbacher J."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Mosbacher J."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Earley T.J."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Earley T.J."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Eid S.R."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Eid S.R."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Hergarden A.C."xsd:string |
| http://purl.uniprot.org/citations/12654248 | http://purl.uniprot.org/core/author | "Hergarden A.C."xsd:string |