| http://purl.uniprot.org/citations/12654513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12654513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12654513 | http://www.w3.org/2000/01/rdf-schema#comment | "In order to examine the possibility that some actions of substance P may be mediated by a variant of the neurokinin-1 (NK-1) receptor, we isolated and sequenced the cDNA encoding a truncated NK-1 receptor from guinea-pig celiac ganglion and brain mRNA by two-step RT-PCR based on the 3'RACE method. The truncated NK-1 receptor sequence corresponded to a splice variant missing the final exon 5, and encoded a 311-amino acid protein that was truncated just after transmembrane domain 7, in an identical position to a truncated variant of the human NK-1 receptor. Thus, the truncated NK-1 receptor lacked the intracellular C-terminus sequence required for the phosphorylation and internalisation of the full-length NK-1 receptor. Using a sensitive one-step semi-quantitative RT-PCR assay, we detected mRNA for both the full length and truncated NK-1 receptors throughout the brain, spinal cord, sensory and autonomic ganglia, and viscera. Truncated NK-1 receptor mRNA was present in lower quantities than mRNA for the full-length NK-1R in all tissues. Highest levels of mRNA for the truncated NK-1 receptor were detected in coeliac ganglion, spinal cord, basal ganglia and hypothalamus. An antiserum to the N-terminus of the NK-1 receptor labelled dendrites of coeliac ganglion neurons that were not labelled with antisera to the C-terminus of the full length NK-1 receptor. These results show that a C-terminally truncated variant of the NK-1 receptor is likely to be widespread in central and peripheral nervous tissue. We predict that this receptor will mediate actions of substance P on neurons where immunohistochemical evidence for a full-length NK-1 receptor is lacking."xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0169-328x(03)00002-0"xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0169-328x(03)00002-0"xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.org/dc/terms/identifier | "doi:10.1016/S0169-328X(03)00002-0"xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/author | "Baker S.J."xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/author | "Baker S.J."xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/author | "Gibbins I.L."xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/author | "Gibbins I.L."xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/author | "Morris J.L."xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/author | "Morris J.L."xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/name | "Brain Res. Mol. Brain Res."xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/name | "Brain Res. Mol. Brain Res."xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/pages | "136-147"xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/pages | "136-147"xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/title | "Cloning of a C-terminally truncated NK-1 receptor from guinea-pig nervous system."xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/title | "Cloning of a C-terminally truncated NK-1 receptor from guinea-pig nervous system."xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/12654513 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12654513 |
| http://purl.uniprot.org/citations/12654513 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12654513 |
| http://purl.uniprot.org/citations/12654513 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12654513 |