| http://purl.uniprot.org/citations/12660156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12660156 | http://www.w3.org/2000/01/rdf-schema#comment | "Ornithine decarboxylase (ODC) is regulated by its metabolic products through a feedback loop that employs a second protein, antizyme 1 (AZ1). AZ1 accelerates the degradation of ODC by the proteasome. We used purified components to study the structural elements required for proteasomal recognition of this ubiquitin-independent substrate. Our results demonstrate that AZ1 acts on ODC to enhance the association of ODC with the proteasome, not the rate of its processing. Substrate-linked or free polyubiquitin chains compete for AZ1-stimulated degradation of ODC. ODC-AZ1 is therefore recognized by the same element(s) in the proteasome that mediate recognition of polyubiquitin chains. The 37 C-terminal amino acids of ODC harbor an AZ1-modulated recognition determinant. Within the ODC C terminus, three subsites are functionally distinguishable. The five terminal amino acids (ARINV, residues 457-461) collaborate with residue C441 to constitute one recognition element, and AZ1 collaborates with additional constituents of the ODC C terminus to generate a second recognition element."xsd:string |
| http://purl.uniprot.org/citations/12660156 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg158"xsd:string |
| http://purl.uniprot.org/citations/12660156 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/12660156 | http://purl.uniprot.org/core/author | "Coffino P."xsd:string |
| http://purl.uniprot.org/citations/12660156 | http://purl.uniprot.org/core/author | "Pickart C.M."xsd:string |
| http://purl.uniprot.org/citations/12660156 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12660156 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/12660156 | http://purl.uniprot.org/core/pages | "1488-1496"xsd:string |
| http://purl.uniprot.org/citations/12660156 | http://purl.uniprot.org/core/title | "Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate."xsd:string |
| http://purl.uniprot.org/citations/12660156 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q15008-mappedCitation-12660156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12660156 |
| http://purl.uniprot.org/uniprot/#_A5LHX3-mappedCitation-12660156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12660156 |
| http://purl.uniprot.org/uniprot/#_O43242-mappedCitation-12660156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12660156 |
| http://purl.uniprot.org/uniprot/#_P40306-mappedCitation-12660156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12660156 |
| http://purl.uniprot.org/uniprot/#_Q13200-mappedCitation-12660156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12660156 |
| http://purl.uniprot.org/uniprot/#_Q14997-mappedCitation-12660156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12660156 |
| http://purl.uniprot.org/uniprot/#_O00231-mappedCitation-12660156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12660156 |
| http://purl.uniprot.org/uniprot/#_O00232-mappedCitation-12660156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12660156 |
| http://purl.uniprot.org/uniprot/#_O00233-mappedCitation-12660156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12660156 |
| http://purl.uniprot.org/uniprot/#_P28062-mappedCitation-12660156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12660156 |
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| http://purl.uniprot.org/uniprot/#_P28066-mappedCitation-12660156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12660156 |