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http://purl.uniprot.org/citations/12663813http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12663813http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12663813http://www.w3.org/2000/01/rdf-schema#comment"Retroviral integration in vivo is mediated by preintegration complexes (PICs) derived from infectious virions. In addition to the integrase enzyme and cDNA substrate, PICs contain a variety of viral and host cell proteins. Whereas two different cell proteins, high-mobility group protein A1 (HMGA1) and the barrier-to-autointegration factor (BAF), were identified as integration cofactors based on activities in in vitro PIC assays, only HMGA1 was previously identified as a PIC component. By using antibodies against known viral and cellular PIC components, we demonstrate here functional coimmunoprecipitation of endogenous BAF protein with human immunodeficiency virus type 1 (HIV-1) PICs. Since integrase protein and integration activity were also coimmunoprecipitated by anti-BAF antibodies, we conclude that BAF is a component of HIV-1 PICs. These data are consistent with the model that BAF functions as an integration cofactor in vivo."xsd:string
http://purl.uniprot.org/citations/12663813http://purl.org/dc/terms/identifier"doi:10.1128/jvi.77.8.5030-5036.2003"xsd:string
http://purl.uniprot.org/citations/12663813http://purl.org/dc/terms/identifier"doi:10.1128/jvi.77.8.5030-5036.2003"xsd:string
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/author"Engelman A."xsd:string
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/author"Engelman A."xsd:string
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/author"Lin C.W."xsd:string
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/author"Lin C.W."xsd:string
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/name"J. Virol."xsd:string
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/name"J. Virol."xsd:string
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/pages"5030-5036"xsd:string
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/pages"5030-5036"xsd:string
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/title"The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes."xsd:string
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/title"The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes."xsd:string
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/volume"77"xsd:string
http://purl.uniprot.org/citations/12663813http://purl.uniprot.org/core/volume"77"xsd:string
http://purl.uniprot.org/citations/12663813http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12663813
http://purl.uniprot.org/citations/12663813http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12663813
http://purl.uniprot.org/citations/12663813http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12663813
http://purl.uniprot.org/citations/12663813http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12663813
http://purl.uniprot.org/uniprot/O75531http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/12663813
http://purl.uniprot.org/uniprot/O75531#attribution-8E85F292621426118078FDAD0956914Chttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/12663813