| http://purl.uniprot.org/citations/12665582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12665582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12665582 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA methylation is involved in a variety of genome functions, including gene control and chromatin dynamics. MBD1 is a transcriptional regulator through the cooperation of a methyl-CpG binding domain, cysteine-rich CXXC domains, and a transcriptional repression domain. A yeast two-hybrid screen was performed to investigate the role of MBD1 in methylation-based transcriptional repression. We report a mediator, MBD1-containing chromatin-associated factor (MCAF), that interacts with the transcriptional repression domain of MBD1. MCAF harbors two conserved domains that allow it to interact with MBD1 and enhancer-like transactivator Sp1. MCAF possesses a coactivator-like activity, and it seems to facilitate Sp1-mediated transcription. In contrast, the MBD1-MCAF complex blocks transcription through affecting Sp1 on methylated promoter regions. These data provide a mechanistic basis for direct inhibition of gene expression via methylation-dependent and histone deacetylation-resistant processes."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.8.2834-2843.2003"xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.8.2834-2843.2003"xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Fujita N."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Fujita N."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Ichimura T."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Ichimura T."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Nakao M."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Nakao M."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Watanabe S."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Watanabe S."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Chiba T."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Chiba T."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Saya H."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Saya H."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Ohkuma Y."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/author | "Ohkuma Y."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/pages | "2834-2843"xsd:string |
| http://purl.uniprot.org/citations/12665582 | http://purl.uniprot.org/core/pages | "2834-2843"xsd:string |