| http://purl.uniprot.org/citations/12665596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12665596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12665596 | http://www.w3.org/2000/01/rdf-schema#comment | "CTF7/ECO1 is an essential yeast gene required for the establishment of sister chromatid cohesion. The findings that CTF7/ECO1, POL30 (PCNA), and CHL12/CTF18 (a replication factor C [RFC] homolog) genetically interact provided the first evidence that the processes of cohesion establishment and DNA replication are intimately coupled-a link now confirmed by other studies. To date, however, it is unknown how Ctf7p/Eco1p function is coupled to DNA replication or whether Ctf7p/Eco1p physically associates with any components of the DNA replication machinery. Here, we report that Ctf7p/Eco1p associates with proteins that perform partially redundant functions in DNA replication. Chl12p/Ctf18p combines with Rfc2p to Rfc5p to form one of three independent RFC complexes. By chromatographic methods, Ctf7p/Eco1p was found to associate with Chl12/Ctf18p and with Rfc2p, Rfc3p, Rfc4p, and Rfc5p. The association between Ctf7p/Eco1p and this RFC complex is biologically relevant in that (i) Ctf7p/Eco1p cosediments with Chl12p/Ctf18p in vivo and (ii) rfc5-1 mutant cells exhibit precocious sister separation. Previous studies revealed that Rfc1p or Rad24p associates with Rfc2p to Rfc5p to form two other RFC complexes independent of Ctf18p-RFC complexes. These Rfc1p-RFC and Rad24p-RFC complexes function in DNA replication or repair and DNA damage checkpoint pathways. Importantly, Ctf7p/Eco1p also associates with Rfc1p and Rad24p, suggesting that these RFC complexes also play critical roles in cohesion establishment. The associations between Ctf7p/Eco1p and RFC subunits provide novel evidence regarding the physical linkage between cohesion establishment and DNA replication. Furthermore, the association of Ctf7p/Eco1p with each of three RFC complexes supplies new insights into the functional redundancy of RFC complexes in cohesion establishment."xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.8.2999-3007.2003"xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.8.2999-3007.2003"xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/author | "Kenna M.A."xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/author | "Kenna M.A."xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/author | "Skibbens R.V."xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/author | "Skibbens R.V."xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/pages | "2999-3007"xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/pages | "2999-3007"xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/title | "Mechanical link between cohesion establishment and DNA replication: Ctf7p/Eco1p, a cohesion establishment factor, associates with three different replication factor C complexes."xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/title | "Mechanical link between cohesion establishment and DNA replication: Ctf7p/Eco1p, a cohesion establishment factor, associates with three different replication factor C complexes."xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/12665596 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12665596 |
| http://purl.uniprot.org/citations/12665596 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12665596 |
| http://purl.uniprot.org/citations/12665596 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12665596 |
| http://purl.uniprot.org/citations/12665596 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12665596 |
| http://purl.uniprot.org/uniprot/P38251 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12665596 |
| http://purl.uniprot.org/uniprot/P43605 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12665596 |