| http://purl.uniprot.org/citations/12670476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12670476 | http://www.w3.org/2000/01/rdf-schema#comment | "Emerin is a nuclear envelope protein whose biological function remains to be elucidated. Mutations of emerin gene cause the Emery-Dreifuss muscular dystrophy, a neuromuscular disorder also linked to mutations of lamin A/C. In this paper, we analyze the interaction between emerin and actin in differentiating mouse myoblasts. We demonstrate that emerin and lamin A/C are bound to actin at the late stages of myotube differentiation and in mature muscle. The interaction involves both nuclear alpha and beta actins and cytoplasmic actin. A serine-threonine phosphatase activity markedly increases emerin-actin binding even in cycling myoblasts. This effect is also observed with purified nuclear fractions in pull-down assay. On the other hand, active protein phosphatase 1, a serine-threonine phosphatase known to associate with lamin A/C, inhibits emerin-actin interaction in myotube extracts. These data provide evidence of a modulation of emerin-actin interaction in muscle cells, possibly through differentiation-related stimuli."xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00415-7"xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/author | "Capanni C."xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/author | "Maraldi N.M."xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/author | "Cenni V."xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/author | "Lattanzi G."xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/author | "Marmiroli S."xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/author | "Merlini L."xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/author | "Squarzoni S."xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/author | "Mattioli E."xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/pages | "764-770"xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/title | "Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts."xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://purl.uniprot.org/core/volume | "303"xsd:string |
| http://purl.uniprot.org/citations/12670476 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12670476 |
| http://purl.uniprot.org/citations/12670476 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12670476 |
| http://purl.uniprot.org/uniprot/#_A2AM95-mappedCitation-12670476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12670476 |
| http://purl.uniprot.org/uniprot/#_B7FAU5-mappedCitation-12670476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12670476 |
| http://purl.uniprot.org/uniprot/#_D3YUF7-mappedCitation-12670476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12670476 |
| http://purl.uniprot.org/uniprot/#_D6RFS0-mappedCitation-12670476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12670476 |
| http://purl.uniprot.org/uniprot/#_Q3THM8-mappedCitation-12670476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12670476 |
| http://purl.uniprot.org/uniprot/#_I7HJS1-mappedCitation-12670476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12670476 |
| http://purl.uniprot.org/uniprot/#_Q8BNX5-mappedCitation-12670476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12670476 |