| http://purl.uniprot.org/citations/12670868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12670868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12670868 | http://www.w3.org/2000/01/rdf-schema#comment | "The abundant and chromatin-associated protein HCF-1 is a critical player in mammalian cell proliferation as well as herpes simplex virus (HSV) transcription. We show here that separate regions of HCF-1 critical for its role in cell proliferation associate with the Sin3 histone deacetylase (HDAC) and a previously uncharacterized human trithorax-related Set1/Ash2 histone methyltransferase (HMT). The Set1/Ash2 HMT methylates histone H3 at Lys 4 (K4), but not if the neighboring K9 residue is already methylated. HCF-1 tethers the Sin3 and Set1/Ash2 transcriptional regulatory complexes together even though they are generally associated with opposite transcriptional outcomes: repression and activation of transcription, respectively. Nevertheless, this tethering is context-dependent because the transcriptional activator VP16 selectively binds HCF-1 associated with the Set1/Ash2 HMT complex in the absence of the Sin3 HDAC complex. These results suggest that HCF-1 can broadly regulate transcription, both positively and negatively, through selective modulation of chromatin structure."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.252103"xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.252103"xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/author | "Herr W."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/author | "Herr W."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/author | "Eisenman R.N."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/author | "Eisenman R.N."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/author | "Laherty C.D."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/author | "Laherty C.D."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/author | "Myers M.P."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/author | "Myers M.P."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/author | "Wysocka J."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/author | "Wysocka J."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/pages | "896-911"xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/pages | "896-911"xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/title | "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/title | "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/12670868 | http://purl.uniprot.org/core/volume | "17"xsd:string |