| http://purl.uniprot.org/citations/12672821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12672821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12672821 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian Enabled (Mena) is a mammalian homologue of Drosophila Enabled (Ena), which genetically interacts with Drosophila Abl tyrosine kinase. The signaling pathway involving c-Abl and Mena (Ena) is not fully understood. To find molecules that participate in the c-Abl/Mena pathway, we searched for Mena-binding proteins using a yeast two-hybrid system. We identified Abl interactor 1 (Abi-1), which is known to interact with c-Abl, as a binding protein for Mena. Binding analysis revealed that the Ena/Vasp homology 1 domain of Mena and the polyproline structure of Abi-1 are necessary for the interaction. The interaction between Mena and Abi-1 was also observed in a mammalian expression system. Importantly, Abi-1 dramatically promoted c-Abl-mediated tyrosine phosphorylation of Mena but not other substrates such as c-Cbl. Mutational analysis demonstrated that the phosphorylation site of Mena is Tyr-296. Our results suggest that Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m301447200"xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m301447200"xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Kojima H."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Kojima H."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Hirose H."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Hirose H."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Hanafusa H."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Hanafusa H."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Shishido T."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Shishido T."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Sukezane T."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Sukezane T."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Tani K."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/author | "Tani K."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/pages | "21685-21692"xsd:string |
| http://purl.uniprot.org/citations/12672821 | http://purl.uniprot.org/core/pages | "21685-21692"xsd:string |