| http://purl.uniprot.org/citations/12676583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12676583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12676583 | http://www.w3.org/2000/01/rdf-schema#comment | "Chk1 kinase coordinates cell cycle progression and preserves genome integrity. Here, we show that chemical or genetic ablation of human Chk1 triggered supraphysiological accumulation of the S phase-promoting Cdc25A phosphatase, prevented ionizing radiation (IR)-induced degradation of Cdc25A, and caused radioresistant DNA synthesis (RDS). The basal turnover of Cdc25A operating in unperturbed S phase required Chk1-dependent phosphorylation of serines 123, 178, 278, and 292. IR-induced acceleration of Cdc25A proteolysis correlated with increased phosphate incorporation into these residues generated by a combined action of Chk1 and Chk2 kinases. Finally, phosphorylation of Chk1 by ATM was required to fully accelerate the IR-induced degradation of Cdc25A. Our results provide evidence that the mammalian S phase checkpoint functions via amplification of physiologically operating, Chk1-dependent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1535-6108(03)00048-5"xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1535-6108(03)00048-5"xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Lukas J."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Lukas J."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Bartek J."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Bartek J."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Khanna K.K."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Khanna K.K."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Falck J."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Falck J."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Schroeder T."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Schroeder T."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Soerensen C.S."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Soerensen C.S."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Zhou B.-B."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Zhou B.-B."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Roennstrand L."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Roennstrand L."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Syljuaesen R.G."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/author | "Syljuaesen R.G."xsd:string |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12676583 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |